OBJECTIVE: This study was conducted to determine the association between lesion length measured on MRI and the severity of mechanical injury in a rat model of spinal cord trauma. MATERIALS AND METHODS: Sprague-Dawley rats were subjected to a modified Allen weight drop injury and killed 4 h after injury. Their fixed, exercised cords were studied with MRI at 1.9 T. RESULTS: There were strong correlations between lesion length on MR images and weight drop height and square root of drop height (r2 = 0.55, p < 0.0001 and r2 = 0.63, p < 0.0001, respectively). The lesion length differences were significant versus controls for all drop heights at p values of < or = 0.002 and for the 2.5 cm animals versus the 5 and 15 cm animals (p = 0.01 and p = 0.0002, respectively), but the lengths of the 5 vs. 15 cm groups only approached significance (p = 0.06). CONCLUSION: These results suggest that lesion length determined on MR images is a reliable indicator of the severity of trauma among animals subjected to weight drop injury.
OBJECTIVE: This study was conducted to determine the association between lesion length measured on MRI and the severity of mechanical injury in a rat model of spinal cord trauma. MATERIALS AND METHODS:Sprague-Dawley rats were subjected to a modified Allen weight drop injury and killed 4 h after injury. Their fixed, exercised cords were studied with MRI at 1.9 T. RESULTS: There were strong correlations between lesion length on MR images and weight drop height and square root of drop height (r2 = 0.55, p < 0.0001 and r2 = 0.63, p < 0.0001, respectively). The lesion length differences were significant versus controls for all drop heights at p values of < or = 0.002 and for the 2.5 cm animals versus the 5 and 15 cm animals (p = 0.01 and p = 0.0002, respectively), but the lengths of the 5 vs. 15 cm groups only approached significance (p = 0.06). CONCLUSION: These results suggest that lesion length determined on MR images is a reliable indicator of the severity of trauma among animals subjected to weight drop injury.
Authors: Phillip D Purdy; Charles L White; Donna L Baer; William H Frawley; R Ross Reichard; G Lee Pride; Christina Adams; Susan Miller; Christa L Hladik; Zerrin Yetkin Journal: AJNR Am J Neuroradiol Date: 2004-09 Impact factor: 3.825
Authors: Bizhan Aarabi; Joshua Olexa; Timothy Chryssikos; Samuel M Galvagno; David S Hersh; Aaron Wessell; Charles Sansur; Gary Schwartzbauer; Kenneth Crandall; Kathirkamanathan Shanmuganathan; J Marc Simard; Harry Mushlin; Mathew Kole; Elizabeth Le; Nathan Pratt; Gregory Cannarsa; Cara D Lomangino; Maureen Scarboro; Carla Aresco; Brian Curry Journal: J Neurotrauma Date: 2018-10-09 Impact factor: 5.269
Authors: Bizhan Aarabi; Noori Akhtar-Danesh; Timothy Chryssikos; Kathirkamanathan Shanmuganathan; Gary T Schwartzbauer; J Marc Simard; Joshua Olexa; Charles A Sansur; Kenneth M Crandall; Harry Mushlin; Matthew J Kole; Elizabeth J Le; Aaron P Wessell; Nathan Pratt; Gregory Cannarsa; Cara Lomangino; Maureen Scarboro; Carla Aresco; Jeffrey Oliver; Nicholas Caffes; Stephen Carbine; Kanami Mori Journal: J Neurotrauma Date: 2019-08-01 Impact factor: 5.269
Authors: J M Simard; P G Popovich; O Tsymbalyuk; J Caridi; R P Gullapalli; M J Kilbourne; V Gerzanich Journal: Spinal Cord Date: 2013-09-17 Impact factor: 2.772