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Literature DB >> 3922883

The influence of Igh-1 genes on the class and subclass distribution of oxazolone-specific antibodies.

G László, E Rajnavölgyi, I Andó, J Gergely.

Abstract

Previous studies have demonstrated that the level of the oxazolone-specific antibody response induced by contact sensitization is under the control of H-2 and Igh-1-linked genes. The aim of the present study was to clarify the role of H-2 and Igh-1 genes in the regulation of antibody affinity and isotype composition of oxazolone-specific antibodies. Analysis of the antibody response to oxazolone has revealed different ratios of IgG2a and IgG2b antibodies in mice carrying the Igh-1b allele and in strains carrying alleles a, c, and e. The characteristic ratio of IgG2a and IgG2b isotypes persisted during the whole period of the primary and secondary antibody response of CBA and CBA-Igb Igh-C congenic mice. The Igh-1-linked genes influenced the isotype distribution and not the affinity of oxazolone-specific antibodies induced by contact sensitization.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1985 PMID： 3922883 DOI： 10.1007/bf00430927

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

44 in total

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Journal: Immunology Date: 1972-09 Impact factor: 7.397

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Journal: Eur J Immunol Date: 1983-12 Impact factor: 5.532

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Journal: J Immunol Date: 1976-12 Impact factor: 5.422

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Journal: J Exp Med Date: 1982-03-01 Impact factor: 14.307

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Journal: J Exp Med Date: 1973-01-01 Impact factor: 14.307