Literature DB >> 8179476

Antineoplastic and antiviral activities of podophyllotoxin related lignans.

M Gordaliza1, M A Castro, M D García-Grávalos, P Ruiz, J M Miguel del Corral, A San Feliciano.   

Abstract

28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1 microM; deoxypodophyllotoxin (1) being the most potent compound in all cases.

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Year:  1994        PMID： 8179476     DOI： 10.1002/ardp.19943270309

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  9 in total

Review 1.  Natural products as leads to anticancer drugs.

Authors:  M Gordaliza
Journal:  Clin Transl Oncol       Date:  2007-12       Impact factor: 3.405

2.  Molecular modelling evaluation of the cytotoxic activity of podophyllotoxin analogues.

Authors:  Md Afroz Alam; Pradeep Kumar Naik
Journal:  J Comput Aided Mol Des       Date:  2008-12-04       Impact factor: 3.686

3.  Reengineered epipodophyllotoxin.

Authors:  Igor V Magedov; Nikolai M Evdokimov; Menuka Karki; Amanda S Peretti; Dustin T Lima; Liliya V Frolova; Mary R Reisenauer; Anntherese E Romero; Paul Tongwa; Alexandr Fonari; Jeff Altig; Snezna Rogelj; Mikhail Yu Antipin; Charles B Shuster; Alexander Kornienko
Journal:  Chem Commun (Camb)       Date:  2012-09-17       Impact factor: 6.222

Review 4.  Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents.

Authors:  Ying-Qian Liu; Jing Tian; Keduo Qian; Xiao-Bo Zhao; Susan L Morris-Natschke; Liu Yang; Xiang Nan; Xuan Tian; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2014-05-14       Impact factor: 12.944

5.  Nanoscale pathogens treated with nanomaterial-like peptides: a platform technology appropriate for future pandemics.

Authors:  Alaa F Nahhas; Alrayan F Nahhas; Thomas J Webster
Journal:  Nanomedicine (Lond)       Date:  2021-05-14       Impact factor: 5.307

6.  Selection of a suitable disc bioassay for the screening of anti-tumor molecules.

Authors:  Fatma Trigui; Pascal Pigeon; Karim Jalleli; Siden Top; Sami Aifa; Mehdi El Arbi
Journal:  Int J Biomed Sci       Date:  2013-12

7.  Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human.

Authors:  Yang Chen; Kaijing Zhao; Fei Liu; Qiushi Xie; Zeyu Zhong; Mingxing Miao; Xiaodong Liu; Li Liu
Journal:  Front Pharmacol       Date:  2016-12-16       Impact factor: 5.810

Review 8.  Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery.

Authors:  Pragya Tiwari; Hanhong Bae
Journal:  Microorganisms       Date:  2022-02-04

Review 9.  Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review.

Authors:  Fazilath Uzma; Chakrabhavi D Mohan; Abeer Hashem; Narasimha M Konappa; Shobith Rangappa; Praveen V Kamath; Bhim P Singh; Venkataramana Mudili; Vijai K Gupta; Chandra N Siddaiah; Srinivas Chowdappa; Abdulaziz A Alqarawi; Elsayed F Abd Allah
Journal:  Front Pharmacol       Date:  2018-04-26       Impact factor: 5.810
  9 in total

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