Literature DB >> 22986348

Reengineered epipodophyllotoxin.

Igor V Magedov1, Nikolai M Evdokimov, Menuka Karki, Amanda S Peretti, Dustin T Lima, Liliya V Frolova, Mary R Reisenauer, Anntherese E Romero, Paul Tongwa, Alexandr Fonari, Jeff Altig, Snezna Rogelj, Mikhail Yu Antipin, Charles B Shuster, Alexander Kornienko.   

Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22986348      PMCID： PMC3563092          DOI： 10.1039/c2cc35044k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

Authors:  Raimond B G Ravelli; Benoît Gigant; Patrick A Curmi; Isabelle Jourdain; Sylvie Lachkar; André Sobel; Marcel Knossow
Journal:  Nature       Date:  2004-03-11       Impact factor: 49.962

2.  Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.

Authors:  S J Cho; Y Kashiwada; K F Bastow; Y C Cheng; K H Lee
Journal:  J Med Chem       Date:  1996-03-29       Impact factor: 7.446

Review 3.  Antitumor properties of podophyllotoxin and related compounds.

Authors:  M Gordaliza; M A Castro; J M del Corral; A S Feliciano
Journal:  Curr Pharm Des       Date:  2000-12       Impact factor: 3.116

4.  Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

Authors:  Igor V Magedov; Liliya Frolova; Madhuri Manpadi; Uma devi Bhoga; Hong Tang; Nikolai M Evdokimov; Olivia George; Kathy Hadje Georgiou; Steffen Renner; Matthäus Getlik; Tiffany L Kinnibrugh; Manuel A Fernandes; Severine Van slambrouck; Wim F A Steelant; Charles B Shuster; Snezna Rogelj; Willem A L van Otterlo; Alexander Kornienko
Journal:  J Med Chem       Date:  2011-05-26       Impact factor: 7.446

5.  Antineoplastic and antiviral activities of podophyllotoxin related lignans.

Authors:  M Gordaliza; M A Castro; M D García-Grávalos; P Ruiz; J M Miguel del Corral; A San Feliciano
Journal:  Arch Pharm (Weinheim)       Date:  1994-03       Impact factor: 3.751

6.  Conformational analysis of podophyllotoxin and its congeners. Structure--activity relationship in microtubule assembly.

Authors:  C F Brewer; J D Loike; S B Horwitz; H Sternlicht; W J Gensler
Journal:  J Med Chem       Date:  1979-03       Impact factor: 7.446

Review 7.  Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.

Authors:  Youngjae You
Journal:  Curr Pharm Des       Date:  2005       Impact factor: 3.116

Review 8.  Recent advances in semisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: an update (2008-2010).

Authors:  M Lv; H Xu
Journal:  Mini Rev Med Chem       Date:  2011-09       Impact factor: 3.862

9.  Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine.

Authors:  S D Cline; T L Macdonald; N Osheroff
Journal:  Biochemistry       Date:  1997-10-21       Impact factor: 3.162

10.  Discovery of podophyllotoxins.

Authors:  T F Imbert
Journal:  Biochimie       Date:  1998-03       Impact factor: 4.079
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.