| Literature DB >> 8179306 |
R J Uitti1, B J Snow, H Shinotoh, F J Vingerhoets, M Hayward, S Hashimoto, J Richmond, S P Markey, C J Markey, D B Calne.
Abstract
We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits were indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.Entities:
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Year: 1994 PMID： 8179306 DOI： 10.1002/ana.410350516
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422