Literature DB >> 8179062

Urinary biological monitoring markers of anticancer drug exposure in oncology nurses.

M A Newman1, B G Valanis, R S Schoeny, S Q Hee.   

Abstract

People handling anticancer drugs or their wastes may absorb these potent genotoxic agents. The aim of this study was to determine the utility of some general urinary markers among 24 female oncology nurses handling these drugs in comparison with 25 "unexposed" nurses. The markers were the Salmonella typhimurium reverse and forward mutation assays, total thioethers, and D-glucaric acid. The reverse mutation assay was the most specific and sensitive marker for anti-cancer drug exposure. Use of the marker battery was no great advantage as a screening tool relative to use of the reverse mutation assay alone. Better recording of work practices in nurse work logs would have improved interpretation of results.

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Year:  1994        PMID： 8179062      PMCID： PMC1615027          DOI： 10.2105/ajph.84.5.852

Source DB:  PubMed          Journal:  Am J Public Health        ISSN： 0090-0036            Impact factor:   9.308


  24 in total

1.  Chromosomal aberrations, sister chromatid exchanges, and urinary thioethers in nurses handling antineoplastic drugs.

Authors:  F Sarto; A Trevisan; R Tomanin; A Canova; M Fiorentino
Journal:  Am J Ind Med       Date:  1990       Impact factor: 2.214

2.  Use of protection by nurses during occupational handling of antineoplastic drugs.

Authors:  B Valanis; M Browne
Journal:  NITA       Date:  1985 May-Jun

3.  Urinary thioether excretion in nurses handling cytotoxic drugs.

Authors:  O Jagun; M Ryan; H A Waldron
Journal:  Lancet       Date:  1982-08-21       Impact factor: 79.321

4.  Lack of mutagenic activity in urine from hospital pharmacists admixing antitumour drugs.

Authors:  N Staiano; J F Gallelli; R H Adamson; S S Thorgeirsson
Journal:  Lancet       Date:  1981-03-14       Impact factor: 79.321

5.  The interaction of chemical compounds with the functional state of the liver. II. Estimation of changes in D-glucaric acid synthesis as a method for diagnosing exposure to xenobiotics.

Authors:  W R Notten; P T Henderson
Journal:  Int Arch Occup Environ Health       Date:  1977       Impact factor: 3.015

6.  Mutagenicity in urine of nurses handling cytostatic drugs.

Authors:  K Falck; P Gröhn; M Sorsa; H Vainio; E Heinonen; L R Holsti
Journal:  Lancet       Date:  1979-06-09       Impact factor: 79.321

7.  Safe handling of chemotherapeutic agents: a report from The Mount Sinai Medical Center.

Authors:  R B Jones; R Frank; T Mass
Journal:  CA Cancer J Clin       Date:  1983 Sep-Oct       Impact factor: 508.702

Review 8.  Detection of human exposure to electrophilic compounds by assay of thioether detoxication products in urine.

Authors:  R van Doorn; C M Leijdekkers; R P Bos; R M Brouns; P T Henderson
Journal:  Ann Occup Hyg       Date:  1981

9.  Antineoplastics: a safety hazard?

Authors:  J P Wilson; D A Solimando
Journal:  Am J Hosp Pharm       Date:  1981-05

10.  Risk of handling injectable antineoplastic agents.

Authors:  R W Anderson; W H Puckett; W J Dana; T V Nguyen; J C Theiss; T S Matney
Journal:  Am J Hosp Pharm       Date:  1982-11
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  2 in total

1.  Structures and processes of care in ambulatory oncology settings and nurse-reported exposure to chemotherapy.

Authors:  Christopher R Friese; Laurel Himes-Ferris; Megan N Frasier; Marjorie C McCullagh; Jennifer J Griggs
Journal:  BMJ Qual Saf       Date:  2011-08-16       Impact factor: 7.035

2.  Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross-sectional multicentre descriptive study.

Authors:  Antoine Villa; Mathieu Molimard; Emmanuelle Bignon; Béatrice Martinez; Magali Rouyer; Simone Mathoulin-Pelissier; Isabelle Baldi; Catherine Verdun-Esquer; Mireille Canal-Raffin
Journal:  BMJ Open       Date:  2019-11-10       Impact factor: 2.692
  2 in total

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