Literature DB >> 8177984

Practical problems in fitting a proportional hazards model to data with updated measurements of the covariates.

D G Altman1, B L De Stavola.   

Abstract

We review and discuss the practical problems encountered when analysing the effect on survival of covariates which are measured repeatedly over time. Specific issues arise over and above those met with the standard proportional hazards model and concern all stages of data preparation, data analysis and interpretation of the results. Data from a randomized clinical trial of patients with primary biliary cirrhosis, on whom several measurements were taken at regular intervals after entry, are presented as an illustration.

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Year:  1994        PMID： 8177984     DOI： 10.1002/sim.4780130402

Source DB:  PubMed          Journal:  Stat Med        ISSN： 0277-6715            Impact factor:   2.373


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