| Literature DB >> 8174424 |
C W Wu1, C W Chi, C K Ho, S L Chien, W Y Liu, F K P'eng, S R Wang.
Abstract
Arginase has been detected in high levels in gastric cancer tissues. The effect of arginase on the activities of splenic natural killer (NK) cell, phytohemagglutinin activated killer (PAK) cell, and interleukin-2 activated killer (LAK) cell in patients with gastric cancer (N = 12) was evaluated in vitro. These activities in patients (N = 10) with trauma and benign lesions were used as control. The splenic NK and PAK cell activities in patients with gastric cancer were significantly lower than in the controls (P < 0.05), whereas LAK cell activity did not have significant difference. Arginase inhibited all splenic killer cell activities to a similar degree between patients with gastric cancer and the controls. The inhibition was dose-related. These data suggest that arginase may play a positive role in the spread of gastric cancer cells. However, LAK may be a potential approach of immunoadoptive therapy in the future.Entities:
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Year: 1994 PMID： 8174424 DOI： 10.1007/bf02087565
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199