Literature DB >> 7240748

In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

S Habu, H Fukui, K Shimamura, M Kasai, Y Nagai, K Okumura, N Tamaoki.   

Abstract

Intravenous injection of anti-asialo GM1, which has been shown to eliminate natural killer (NK) activity in vitro in the presence of complement, completely abolished NK activity against lymphoma cell line (YAC-1) in spleen cells from athymic nude mice as well as from conventional mice. An immunofluorescence study revealed a decreased number of asialo GM1 positive cells in the spleens of mice injected with anti-asialo GM1 than in those of mice injected with normal rabbit serum. In the nude mice with reduced NK activity, incidence of tumor take and the growth were enhanced when syngeneic (RL male-1), and allogeneic (YAC-1) tumors and human tumors were transplanted subcutaneously. These results strongly suggest that NK cells play an important role in transplanted-tumor growth in vivo.

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Year:  1981        PMID： 7240748

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  136 in total

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8.  Time course study of H-2 and other antigen expression by hybrids of a myeloma cell line with inflammatory macrophages.

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9.  Early-appearing tumour-infiltrating natural killer cells play a crucial role in the generation of anti-tumour T lymphocytes.

Authors:  S Kurosawa; M Harada; G Matsuzaki; Y Shinomiya; H Terao; N Kobayashi; K Nomoto
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10.  Natural killer (NK) cells and graft-versus-host disease (GVHD): no correlation between the NK cell levels and GVHD in the murine P----F1 model.

Authors:  K Varkila; M Hurme
Journal:  Immunology       Date:  1985-01       Impact factor: 7.397
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