Literature DB >> 8172938

Decreased agonist-stimulated Ca2+ response in neutrophils from patients under chronic lithium therapy.

U Förstner1, M Bohus, P J Gebicke-Härter, B Baumer, M Berger, D van Calker.   

Abstract

The agonist-stimulated increase in the intracellular concentration of free Ca2+ ([Ca2+]i) was determined in neutrophils from patients under chronic lithium therapy and a control group of age- and sex-matched healthy drug-free subjects. Cells were stimulated with the chemotactic peptide formylmethionylleucylphenylalanin (fMLP) and the Ca2+ concentrations measured with the fluorescent Ca2+ indicator Fura-2. The Ca2+ response to stimulation with fMLP was significantly attenuated in neutrophils from patients chronically treated with lithium. The data suggest that lithium treatment inhibits the inositol phospholipid second messenger generating system in human cells and support the results of earlier inositol phosphate measurements in fMLP-stimulated neutrophils.

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Year:  1994        PMID： 8172938     DOI： 10.1007/bf02191581

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  22 in total

1.  Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders.

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Review 2.  Second messengers and affective illness. Focus on the phosphoinositide cycle.

Authors:  S H Snyder
Journal:  Pharmacopsychiatry       Date:  1992-01       Impact factor: 5.788

3.  Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients.

Authors:  S L Dubovsky; J Murphy; M Thomas; J Rademacher
Journal:  Am J Psychiatry       Date:  1992-01       Impact factor: 18.112

Review 4.  Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium.

Authors:  J M Baraban; P F Worley; S H Snyder
Journal:  Am J Psychiatry       Date:  1989-10       Impact factor: 18.112

5.  Nerve growth factor potentiates the hormone-stimulated intracellular accumulation of inositol phosphates and Ca2+ in rat PC12 pheochromocytoma cells: comparison with the effect of epidermal growth factor.

Authors:  D van Calker; K Takahata; R Heumann
Journal:  J Neurochem       Date:  1989-01       Impact factor: 5.372

Review 6.  Signal transduction and cytoskeletal activation in the neutrophil.

Authors:  G M Omann; R A Allen; G M Bokoch; R G Painter; A E Traynor; L A Sklar
Journal:  Physiol Rev       Date:  1987-01       Impact factor: 37.312

7.  Separation of lymphocytes, granulocytes, and monocytes from human blood using iodinated density gradient media.

Authors:  A Bøyum
Journal:  Methods Enzymol       Date:  1984       Impact factor: 1.600

8.  Secretagogue-induced phosphoinositide metabolism in human leucocytes.

Authors:  R W Dougherty; P P Godfrey; P C Hoyle; J W Putney; R J Freer
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

9.  Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder.

Authors:  S L Dubovsky; M Thomas; A Hijazi; J Murphy
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270

10.  Cytosolic free [Ca2+] in single T-lymphocytes from depressed patients and healthy controls.

Authors:  B Vollmayr; J B Aldenhoff
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270
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  1 in total

Review 1.  Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers.

Authors:  Jung Goo Lee; Young Sup Woo; Sung Woo Park; Dae-Hyun Seog; Mi Kyoung Seo; Won-Myong Bahk
Journal:  Clin Psychopharmacol Neurosci       Date:  2022-05-31       Impact factor: 3.731
  1 in total

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