S J Veldhuyzen van Zanten1. 1. Division of Gastroenterology, Dalhousie University, Victoria General Hospital, Halifax Nova Scotia, Canada.
Abstract
STUDY AIM: To critically appraise the use of outcome measures in treatment trials of Helicobacter pylori positive non-ulcer dyspepsia patients. METHODS: Meta-analysis of published randomized placebo-controlled clinical trials. RESULTS: Significant methodological problems were detected in all seven retrieved studies. There is marked variation in measurement of: symptoms, scales used to assess severity of dyspepsia, use of global assessments and methods used to determine whether a change occurred in symptom severity. CONCLUSION: Much more attention needs to be paid to outcome measures in non-ulcer dyspepsia trials and consensus on this should be reached by investigators in this area.
STUDY AIM: To critically appraise the use of outcome measures in treatment trials of Helicobacter pylori positive non-ulcer dyspepsiapatients. METHODS: Meta-analysis of published randomized placebo-controlled clinical trials. RESULTS: Significant methodological problems were detected in all seven retrieved studies. There is marked variation in measurement of: symptoms, scales used to assess severity of dyspepsia, use of global assessments and methods used to determine whether a change occurred in symptom severity. CONCLUSION: Much more attention needs to be paid to outcome measures in non-ulcer dyspepsia trials and consensus on this should be reached by investigators in this area.
Authors: M Vardi; B L Cryer; M Cohen; A Lanas; T J Schnitzer; P Lapuerta; M A Goldsmith; L Laine; G Doros; Y Liu; A I McIntosh; C P Cannon; D L Bhatt Journal: Aliment Pharmacol Ther Date: 2015-05-29 Impact factor: 8.171
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