R L Jaakkimainen1, E Boyle, F Tudiver. 1. Institute for Clinical Evaluative Sciences, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada M4N 3M5. liisa.jaakkimainen@ices.on.ca
Abstract
OBJECTIVES: To examine the association between Helicobacter pylori infection and non-ulcer dyspepsia, and to assess the effect of eradicating H pylori on dyspeptic symptoms in patients with non-ulcer dyspepsia. DESIGN: Systematic review and meta-analysis of (a) observational studies examining the association between Helicobacter pylori infection and non-ulcer dyspepsia (association studies), and (b) therapeutic trials examining the association between eradication of H pylori and dyspeptic symptoms in patients with non-ulcer dyspepsia (eradication trials). DATA SOURCES: Randomised controlled trials and observational studies conducted worldwide and published between January 1983 and March 1999. MAIN OUTCOME MEASURES: Summary odds ratios and summary symptom scores. RESULTS: 23 association studies and 5 eradication trials met the inclusion criteria. In the association studies the summary odds ratio for H pylori infection in patients with non-ulcer dyspepsia was 1.6 (95% confidence interval 1.4 to 1.8). In the eradication trials the summary odds ratio for improvement in dyspeptic symptoms in patients with non-ulcer dyspepsia in whom H pylori was eradicated was 1.9 (1.3 to 2.6). CONCLUSIONS: Some evidence shows an association between H pylori infection and dyspeptic symptoms in patients referred to gastroenterologists. An improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom H pylori was eradicated.
OBJECTIVES: To examine the association between Helicobacter pyloriinfection and non-ulcer dyspepsia, and to assess the effect of eradicating H pylori on dyspeptic symptoms in patients with non-ulcer dyspepsia. DESIGN: Systematic review and meta-analysis of (a) observational studies examining the association between Helicobacter pyloriinfection and non-ulcer dyspepsia (association studies), and (b) therapeutic trials examining the association between eradication of H pylori and dyspeptic symptoms in patients with non-ulcer dyspepsia (eradication trials). DATA SOURCES: Randomised controlled trials and observational studies conducted worldwide and published between January 1983 and March 1999. MAIN OUTCOME MEASURES: Summary odds ratios and summary symptom scores. RESULTS: 23 association studies and 5 eradication trials met the inclusion criteria. In the association studies the summary odds ratio for H pylori infection in patients with non-ulcer dyspepsia was 1.6 (95% confidence interval 1.4 to 1.8). In the eradication trials the summary odds ratio for improvement in dyspeptic symptoms in patients with non-ulcer dyspepsia in whom H pylori was eradicated was 1.9 (1.3 to 2.6). CONCLUSIONS: Some evidence shows an association between H pyloriinfection and dyspeptic symptoms in patients referred to gastroenterologists. An improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom H pylori was eradicated.
Authors: J C Wu; J J Sung; E K Ng; M Y Go; W B Chan; F K Chan; W K Leung; C L Choi; S C Chung Journal: Am J Gastroenterol Date: 1999-07 Impact factor: 10.864
Authors: Francesco di Mario; Nicoletta Stefani; Nadia Dal Bò; Massimo Rugge; Alberto Pilotto; Giulia Martina Cavestro; Lucas Giovanni Cavallaro; Angelo Franzé; Gioacchino Leandro Journal: Dig Dis Sci Date: 2005-12 Impact factor: 3.199
Authors: S J Veldhuyzen van Zanten; N Flook; N Chiba; D Armstrong; A Barkun; M Bradette; A Thomson; F Bursey; P Blackshaw; D Frail; P Sinclair Journal: CMAJ Date: 2000-06-13 Impact factor: 8.262
Authors: Javier P Gisbert; Xavier Calvet; Juan Ferrándiz; Juan Mascort; Pablo Alonso-Coello; Mercè Marzo Journal: Aten Primaria Date: 2012-10-01 Impact factor: 1.137