AIM: To monitor the anti-HIV-1 activity of antiretroviral agents in patients with HIV-1 infection. METHOD: Quantification of viral RNA copy in plasma or serum using a polymerase chain reaction method coupled with reverse transcription. CONCLUSIONS: The HIV-1 RNA copy number represents the HIV-1 viremia status in patients with HIV-1 infection. This copy number is likely to be useful in monitoring the effectiveness of antiviral therapy and the method is likely to be built into every clinical trial of anti-HIV-1 therapy in the near future.
AIM: To monitor the anti-HIV-1 activity of antiretroviral agents in patients with HIV-1 infection. METHOD: Quantification of viral RNA copy in plasma or serum using a polymerase chain reaction method coupled with reverse transcription. CONCLUSIONS: The HIV-1 RNA copy number represents the HIV-1 viremia status in patients with HIV-1 infection. This copy number is likely to be useful in monitoring the effectiveness of antiviral therapy and the method is likely to be built into every clinical trial of anti-HIV-1 therapy in the near future.
Authors: T Shirasaka; M F Kavlick; T Ueno; W Y Gao; E Kojima; M L Alcaide; S Chokekijchai; B M Roy; E Arnold; R Yarchoan Journal: Proc Natl Acad Sci U S A Date: 1995-03-14 Impact factor: 11.205
Authors: Margaret L Green; Wendy Leisenring; Hu Xie; T Christopher Mast; Yadong Cui; Brenda M Sandmaier; Mohamed L Sorror; Sonia Goyal; Sezen Özkök; Jessica Yi; Farah Sahoo; Louise E Kimball; Keith R Jerome; Morgan A Marks; Michael Boeckh Journal: Lancet Haematol Date: 2016-02-20 Impact factor: 18.959