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Literature DB >> 8157041

The effect of probenecid on paracetamol metabolism and pharmacokinetics.

Abstract

The influence of probenecid on the pharmacokinetics of paracetamol was investigated in a group of healthy volunteers. Pretreatment with probenecid caused a significant decrease in paracetamol clearance (6.23 to 3.42 ml.min-1.kg-1). The urinary excretion of paracetamol sulphate (243 to 193 mg); and paracetamol glucuronide (348 to 74.5 mg) were significantly reduced, whereas that of paracetamol was unchanged. Probenecid was shown to be an uncompetitive inhibitor of paracetamol glucuronidation in vitro, using rat liver microsomes.

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Year: 1993 PMID： 8157041 DOI： 10.1007/bf00315313

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

17 in total

1. Paracetamol metabolism following overdosage: application of high performance liquid chromatography.

Authors: D Howie; P I Adriaenssens; L F Prescott
Journal: J Pharm Pharmacol Date: 1977-04 Impact factor: 3.765

2. Renal tubular transport of paracetamol and its conjugates in the dog.

Authors: G G Duggin; G H Mudge
Journal: Br J Pharmacol Date: 1975-07 Impact factor: 8.739

3. The renal excretion of indomethacin and its inhibition by probenecid.

Authors: M D Skeith; P A Simkin; L A Healey
Journal: Clin Pharmacol Ther Date: 1968 Jan-Feb Impact factor: 6.875

4. Drug biotransformation interactions in man. 3. Acetaminophen and salicylamide.

Authors: G Levy; H Yamada
Journal: J Pharm Sci Date: 1971-02 Impact factor: 3.534

5. Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex.

Authors: P de Miranda; S S Good; R Yarchoan; R V Thomas; M R Blum; C E Myers; S Broder
Journal: Clin Pharmacol Ther Date: 1989-11 Impact factor: 6.875

6. Probenecid-clofibrate interaction.

Authors: J R Veenendaal; P M Brooks; P J Meffin
Journal: Clin Pharmacol Ther Date: 1981-03 Impact factor: 6.875

7. Medicinal azides. Part 3. The metabolism of the investigational antitumour agent meta-azidopyrimethamine in mouse tissue in vitro.

Authors: F Kamali; A Gescher; J A Slack
Journal: Xenobiotica Date: 1988-10 Impact factor: 1.908

8. Effect of probenecid on the excretion of ampicillin in human bile.

Authors: J Kampmann; F Lindahl; J M Hansen; K Siersbaek-Nielsen
Journal: Br J Pharmacol Date: 1973-04 Impact factor: 8.739

Review 9. Kinetics and metabolism of paracetamol and phenacetin.

Authors: L F Prescott
Journal: Br J Clin Pharmacol Date: 1980-10 Impact factor: 4.335

10. Prolongation and enhancement of serum methotrexate concentrations by probenecid.

Authors: G W Aherne; E Piall; V Marks; G Mould; W F White
Journal: Br Med J Date: 1978-04-29

8 in total

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Journal: Br J Clin Pharmacol Date: 2013-02 Impact factor: 4.335

2. Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.

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Journal: Antimicrob Agents Chemother Date: 2009-06-29 Impact factor: 5.191

3. Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach.

Authors: Todd J Zurlinden; Brad Reisfeld
Journal: Eur J Drug Metab Pharmacokinet Date: 2015-01-31 Impact factor: 2.441

4. Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid.

Authors: Cornelia B Landersdorfer; Carl M J Kirkpatrick; Martina Kinzig; Jürgen B Bulitta; Ulrike Holzgrabe; Ulrich Jaehde; Andreas Reiter; Kurt G Naber; Michael Rodamer; Fritz Sörgel
Journal: Br J Clin Pharmacol Date: 2010-02 Impact factor: 4.335

5. Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia.

Authors: Dong-Wook Kim; Eugene Y Tan; Yu Jin; Sahee Park; Michael Hayes; Eren Demirhan; Horst Schran; Yanfeng Wang
Journal: Br J Clin Pharmacol Date: 2011-02 Impact factor: 4.335

6. Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling.

Authors: Todd J Zurlinden; Brad Reisfeld
Journal: Eur J Drug Metab Pharmacokinet Date: 2017-02 Impact factor: 2.441

7. Effect of probenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal.

Authors: J I Macdonald; S M Wallace; R J Herman; R K Verbeeck
Journal: Eur J Clin Pharmacol Date: 1995 Impact factor: 2.953

8. Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Authors: Marlon J A Jetten; Ainhoa Ruiz-Aracama; Maarten L J Coonen; Sandra M Claessen; Marcel H M van Herwijnen; Arjen Lommen; Joost H M van Delft; Ad A C M Peijnenburg; Jos C S Kleinjans
Journal: Arch Toxicol Date: 2015-06-24 Impact factor: 5.153

8 in total