Literature DB >> 8157033

Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father. A case report.

R Moser1, I Fae, A Neumeister, M Pober, I Mutz, S Panzer.   

Abstract

We report a case of neonatal allo-immune thrombocytopenia due to fetomaternal human platelet antigen (HPA)-1 incompatibility. Anit-HPA-1b antibodies were detectable in maternal serum. Repeated treatment of the infant with high-dose IgG effectively raised platelet counts transiently, but the patient remained thrombocytopenic for more than 6 weeks. Serological and DNA analysis revealed that the mother was homozygous HPA-1a and the father homozygous HPA-1b.

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Year:  1994        PMID： 8157033     DOI： 10.1007/bf01959215

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  8 in total

1.  Alloimmune thrombocytopenia. Review from a neonatal intensive care unit.

Authors:  V S Blanchette; M A Peters; K Pegg-Feige
Journal:  Curr Stud Hematol Blood Transfus       Date:  1986

2.  Neonatal alloimmune amegakaryocytosis. Case report.

Authors:  N Bizzaro; G Dianese
Journal:  Vox Sang       Date:  1988       Impact factor: 2.144

3.  High-dose intravenous immunoglobulin for post-transfusion purpura.

Authors:  T Becker; S Panzer; D Maas; V Kiefel; R Sprenger; M Kirschbaum; C Mueller-Eckhardt
Journal:  Br J Haematol       Date:  1985-09       Impact factor: 6.998

4.  348 cases of suspected neonatal alloimmune thrombocytopenia.

Authors:  C Mueller-Eckhardt; V Kiefel; A Grubert; H Kroll; M Weisheit; S Schmidt; G Mueller-Eckhardt; S Santoso
Journal:  Lancet       Date:  1989-02-18       Impact factor: 79.321

5.  Genotyping provides a reliable tool for the determination of the platelet antigen system HPA-1 in Glanzmann's thrombasthenia.

Authors:  M Pober; P A Kyrle; S Panzer
Journal:  Br J Haematol       Date:  1993-09       Impact factor: 6.998

6.  Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PIA1) and HPA-1b (Zwb/PIA2).

Authors:  R W Kuijpers; A E von dem Borne; V Kiefel; C M Eckhardt; A H Waters; B Zupanska; D Barz; E Taaning; A Termijtelen; W H Ouwehand
Journal:  Hum Immunol       Date:  1992-08       Impact factor: 2.850

7.  HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases.

Authors:  C Kaplan; M C Morel-Kopp; H Kroll; V Kiefel; N Schlegel; N Chesnel; C Mueller-Eckhardt
Journal:  Br J Haematol       Date:  1991-07       Impact factor: 6.998

8.  Neonatal alloimmune thrombocytopenia due to fetomaternal Zwb incompatibility.

Authors:  C Mueller-Eckhardt; T Becker; M Weisheit; C Witz; S Santoso
Journal:  Vox Sang       Date:  1986       Impact factor: 2.144
  8 in total

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