Literature DB >> 8153627

A mass spectrometric solution to the address problem of combinatorial libraries.

C L Brummel1, I N Lee, Y Zhou, S J Benkovic, N Winograd.   

Abstract

The molecular weights of femtomole quantities of small peptides attached to polystyrene beads have been determined with imaging time-of-flight secondary ion mass spectrometry. The analysis is made possible by the selective clipping of the bond linking the peptide to a bead with trifluoroacetic acid vapor before the secondary ion mass spectrometry assay. The approach can be applied to large numbers of 30- to 60-micrometer polystyrene beads for the direct characterization of massive combinatorial libraries.

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Year:  1994        PMID： 8153627     DOI： 10.1126/science.8153627

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Peptomers: a versatile approach for the preparation of diverse combinatorial peptidomimetic bead libraries.

Authors:  S Ostergaard; A Holm
Journal:  Mol Divers       Date:  1997       Impact factor: 2.943

Review 2.  Encoding strategies in combinatorial chemistry.

Authors:  A W Czarnik
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

Review 3.  Design, synthesis and use of binary encoded synthetic chemical libraries.

Authors:  J J Baldwin
Journal:  Mol Divers       Date:  1996-10       Impact factor: 2.943

Review 4.  Synthetic library techniques: subjective (biased and generic) thoughts and views.

Authors:  V Krchnák; M Lebl
Journal:  Mol Divers       Date:  1996-05       Impact factor: 2.943

5.  A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-amino-3-(2-nitrophenyl)propionic acid.

Authors:  B B Brown; D S Wagner; H M Geysen
Journal:  Mol Divers       Date:  1995-09       Impact factor: 2.943

6.  Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry.

Authors:  Laura M Sanchez; Matthew E Curtis; Bianca E Bracamonte; Kenji L Kurita; Gabriel Navarro; O David Sparkman; Roger G Linington
Journal:  Org Lett       Date:  2011-06-24       Impact factor: 6.005

7.  Static secondary ion mass spectrometry to monitor solid-phase peptide synthesis.

Authors:  D Maux; C Enjalbal; J Martinez; J L Aubagnac; R Combarieu
Journal:  J Am Soc Mass Spectrom       Date:  2001-10       Impact factor: 3.109

Review 8.  Dissection of an antibody-catalyzed reaction.

Authors:  J D Stewart; J F Krebs; G Siuzdak; A J Berdis; D B Smithrud; S J Benkovic
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

9.  Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries.

Authors:  Gary L Juskowiak; Christopher J McGee; John Greaves; David L Van Vranken
Journal:  J Comb Chem       Date:  2008-07-26

10.  Correlated matrix-assisted laser desorption/ionization mass spectrometry and fluorescent imaging of photocleavable peptide-coded random bead-arrays.

Authors:  Mark J Lim; Ziying Liu; Karen I Braunschweiger; Amany Awad; Kenneth J Rothschild
Journal:  Rapid Commun Mass Spectrom       Date:  2014-01-15       Impact factor: 2.419
  10 in total

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