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Literature DB >> 8150707

3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity.

B E Roggo¹, F Petersen, R Delmendo, H B Jenny, H H Peter, J Roesel.

Abstract

In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a recently described structural class of secondary metabolites. The HIV-1 activity of resistomycin (7) has not been reported before.

Entities: Chemical Species

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Year: 1994 PMID： 8150707 DOI： 10.7164/antibiotics.47.136

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

12 in total

Review 1. Domino syntheses of bioactive tetronic and tetramic acids.

Authors: Rainer Schobert
Journal: Naturwissenschaften Date: 2006-08-31

2. F-36316 A and B, novel vasoactive compounds, isolated from Incrucipulum sp. SANK 10414.

Authors: Yuki Hirota-Takahata; Yoko Ishimoto; Emi Kurosawa; Yuko Iwadate; Yoshiko Onozawa; Isshin Tanaka; Masahiro Tanaka; Hideki Kobayashi
Journal: J Antibiot (Tokyo) Date: 2017-08-09 Impact factor: 2.649

3. Microwave-assisted multicomponent reaction in water leading to highly regioselective formation of benzo[f]azulen-1-ones.

Authors: Shu-Liang Wang; Chuang Cheng; Fei-Yue Wu; Bo Jiang; Feng Shi; Shu-Jiang Tu; Trideep Rajale; Guigen Li
Journal: Tetrahedron Date: 2011-06-24 Impact factor: 2.457

4. Regiospecific hydration of gamma-hydroxy-alpha,beta-acetylenic esters: a novel asymmetric synthesis of tetronic acids.

Authors: Amaresh R Rajaram; Lin Pu
Journal: Org Lett Date: 2006-05-11 Impact factor: 6.005

5. Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1).

Authors: Ming Hung Lin; Atikul Islam; Yen-Hui Liu; Chia-Wei Weng; Jun-Han Zhan; Ru-Hao Liang; Alexander S Tikhomirov; Andrey E Shchekotikhin; Pin Ju Chueh
Journal: Am J Cancer Res Date: 2022-03-15 Impact factor: 6.166

3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity.

Review 1. Domino syntheses of bioactive tetronic and tetramic acids.

2. F-36316 A and B, novel vasoactive compounds, isolated from Incrucipulum sp. SANK 10414.

3. Microwave-assisted multicomponent reaction in water leading to highly regioselective formation of benzo[f]azulen-1-ones.

4. Regiospecific hydration of gamma-hydroxy-alpha,beta-acetylenic esters: a novel asymmetric synthesis of tetronic acids.

5. Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1).

Review 6. Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives.

7. Tetramic and tetronic acids as scaffolds in bioinorganic and bioorganic chemistry.

8. Synthesis and Crystal Structure Characterization of Zinc (II) Tetronic Acid Complexes.

9. Chlorxanthomycin, a fluorescent, chlorinated, pentacyclic pyrene from a Bacillus sp.

10. 4,4'-Dianilino-3,3'-(4-chloro-benzyl-idene)bis-[furan-2(5H)-one].