| Literature DB >> 21731115 |
Shu-Liang Wang1, Chuang Cheng, Fei-Yue Wu, Bo Jiang, Feng Shi, Shu-Jiang Tu, Trideep Rajale, Guigen Li.
Abstract
Microwave-assisted three-component reaction has been established for the regioselective synthesis of benzo[f]azulen-1-ones. The reaction was performed in aqueous media under microwave irradiation by using readily available and inexpensive starting materials. A total of 38 examples were examined to show a broad substrate scope and good overall yields (70-89%). The present new synthesis shows attractive green chemistry characteristics, such as the use of water as reaction media, concise one-pot conditions, short reaction periods (7-24 min), easy work-up/purification and reduced waste production without the use of any strong acids or metal promoters.Entities:
Year: 2011 PMID： 21731115 PMCID： PMC3124679 DOI： 10.1016/j.tet.2011.05.002
Source DB: PubMed Journal: Tetrahedron ISSN： 0040-4020 Impact factor: 2.457