Literature DB >> 8146199

Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms.

R H Farkas1, S Nakajima, Y Nakajima.   

Abstract

The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.

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Year:  1994        PMID： 8146199      PMCID： PMC43469          DOI： 10.1073/pnas.91.7.2853

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

Review 1.  Alzheimer's disease: a disorder of cortical cholinergic innervation.

Authors:  J T Coyle; D L Price; M R DeLong
Journal:  Science       Date:  1983-03-11       Impact factor: 47.728

2.  Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6).

Authors:  M M Mesulam; E J Mufson; B H Wainer; A I Levey
Journal:  Neuroscience       Date:  1983-12       Impact factor: 3.590

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Authors:  P R Stanfield; Y Nakajima; K Yamaguchi
Journal:  Nature       Date:  1985 Jun 6-12       Impact factor: 49.962

4.  Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

Authors:  G M Bokoch; T Katada; J K Northup; M Ui; A G Gilman
Journal:  J Biol Chem       Date:  1984-03-25       Impact factor: 5.157

5.  Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices.

Authors:  M Goedert; R D Pinnock; C P Downes; P W Mantyh; P C Emson
Journal:  Brain Res       Date:  1984-12-03       Impact factor: 3.252

6.  Senile dementia of the Alzheimer type.

Authors:  R D Terry; R Katzman
Journal:  Ann Neurol       Date:  1983-11       Impact factor: 10.422

7.  Action of neurotensin on spinal cord neurons in the rat.

Authors:  P Stanzione; W Zieglgänsberger
Journal:  Brain Res       Date:  1983-05-23       Impact factor: 3.252

8.  Neurotensin depolarizes substantia nigra dopamine neurones.

Authors:  R D Pinnock
Journal:  Brain Res       Date:  1985-07-08       Impact factor: 3.252

9.  Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum.

Authors:  A I Levey; B H Wainer; E J Mufson; M M Mesulam
Journal:  Neuroscience       Date:  1983-05       Impact factor: 3.590

10.  Neurotensin: topographical distribution in rat brain by immunohistochemistry.

Authors:  L Jennes; W E Stumpf; P W Kalivas
Journal:  J Comp Neurol       Date:  1982-09-20       Impact factor: 3.215
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  13 in total

1.  Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons.

Authors:  D Bajic; M Koike; A M Albsoul-Younes; S Nakajima; Y Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205

Review 2.  The role of neurotensin in central nervous system pathophysiology: what is the evidence?

Authors:  Fannie St-Gelais; Claudia Jomphe; Louis-Eric Trudeau
Journal:  J Psychiatry Neurosci       Date:  2006-07       Impact factor: 6.186

3.  Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neurons.

Authors:  B M Velimirovic; K Koyano; S Nakajima; Y Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

4.  The role of N-, Q- and R-type Ca2+ channels in feedback inhibition of ACh release from rat basal forebrain neurones.

Authors:  T G Allen
Journal:  J Physiol       Date:  1999-02-15       Impact factor: 5.182

5.  Positive feedback by a potassium-selective inward rectifier enhances tuning in vertebrate hair cells.

Authors:  M B Goodman; J J Art
Journal:  Biophys J       Date:  1996-07       Impact factor: 4.033

6.  Single-channel properties of the nonselective cation conductance induced by neurotensin in dopaminergic neurons.

Authors:  P Y Chien; R H Farkas; S Nakajima; Y Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

7.  Neurotensin inhibition of the hyperpolarization-activated cation current (Ih) in the rat substantia nigra pars compacta implicates the protein kinase C pathway.

Authors:  L Cathala; D Paupardin-Tritsch
Journal:  J Physiol       Date:  1997-08-15       Impact factor: 5.182

8.  Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor.

Authors:  D E Garcia; S Brown; B Hille; K Mackie
Journal:  J Neurosci       Date:  1998-04-15       Impact factor: 6.167

9.  Nonselective cation channels are essential for maintaining intracellular Ca2+ levels and spontaneous firing activity in the midbrain dopamine neurons.

Authors:  Shin Hye Kim; Yu Mi Choi; Jin Yong Jang; Sungkwon Chung; Yun Kyung Kang; Myoung Kyu Park
Journal:  Pflugers Arch       Date:  2007-05-10       Impact factor: 3.657

10.  Effects of neurotensin on rat supraoptic nucleus neurones in vitro.

Authors:  K Kirkpatrick; C W Bourque
Journal:  J Physiol       Date:  1995-01-15       Impact factor: 5.182
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