Literature DB >> 8137121

On the mechanism of action of quinolone drugs.

M Palumbo1, B Gatto, G Zagotto, G Palù.   

Abstract

Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.

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Year:  1993        PMID： 8137121     DOI： 10.1016/0966-842x(93)90138-h

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  8 in total

1.  Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).

Authors:  F M Barnard; A Maxwell
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

Review 2.  Instructive Advances in Chemical Microbiology Inspired by Nature's Diverse Inventory of Molecules.

Authors:  Ke Liu; Robert W Huigens
Journal:  ACS Infect Dis       Date:  2020-01-06       Impact factor: 5.084

Review 3.  Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.

Authors:  Yasmeen Abouelhassan; Aaron T Garrison; Hongfen Yang; Alejandra Chávez-Riveros; Gena M Burch; Robert W Huigens
Journal:  J Med Chem       Date:  2019-04-18       Impact factor: 7.446

4.  New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action.

Authors:  Cristina Parolin; Barbara Gatto; Claudia Del Vecchio; Teresa Pecere; Enzo Tramontano; Violetta Cecchetti; Arnaldo Fravolini; Sara Masiero; Manlio Palumbo; Giorgio Palù
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

5.  Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.

Authors:  C Sissi; E Vazquez; A Chemello; L A Mitchenall; A Maxwell; M Palumbo
Journal:  Antimicrob Agents Chemother       Date:  2009-10-26       Impact factor: 5.191

6.  Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

Authors:  J Vila; J Ruiz; F Marco; A Barcelo; P Goñi; E Giralt; T Jimenez de Anta
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

7.  Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.

Authors:  F Reyna; M Huesca; V González; L Y Fuchs
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191

8.  Quinolone-DNA interaction: sequence-dependent binding to single-stranded DNA reflects the interaction within the gyrase-DNA complex.

Authors:  Christian G Noble; Faye M Barnard; Anthony Maxwell
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191
  8 in total

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