Literature DB >> 8135805

Rat heart fatty acid-binding protein content is increased in experimental diabetes.

J F Glatz1, E van Breda, H A Keizer, Y F de Jong, J R Lakey, R V Rajotte, A Thompson, G J van der Vusse, G D Lopaschuk.   

Abstract

Cytoplasmic fatty acid-binding protein (FABP) was assayed immunochemically in hearts from rats with insulin-dependent (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM). FABP contents were 34% higher in IDDM and 103% higher in NIDDM hearts than in respective age-matched controls. FABP levels returned to control values when islets of Langerhans were transplanted into diabetic IDDM animals. In the diabetic hearts the activity of fructose-6-phosphate kinase decreased (IDDM and NIDDM animals), while that of 3-hydroxyacyl-CoA dehydrogenase increased (NIDDM animals only). These data indicate that experimental diabetes induces a marked increase of the FABP content of rat heart and suggests that this protein is involved in the enhanced fatty acid utilization by the diabetic heart.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8135805     DOI： 10.1006/bbrc.1994.1276

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Beta(3)-adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes.

Authors:  Jeffrey A Deiuliis; Li-Fen Liu; Martha A Belury; Jong S Rim; Sangsu Shin; Kichoon Lee
Journal:  Lipids       Date:  2010-05-28       Impact factor: 1.880

2.  A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes.

Authors:  M M Pelsers; J T Lutgerink; F A Nieuwenhoven; N N Tandon; G J van der Vusse; J W Arends; H R Hoogenboom; J F Glatz
Journal:  Biochem J       Date:  1999-02-01       Impact factor: 3.857

3.  Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats.

Authors:  Danny M Hasselbaink; Jan F C Glatz; Joost J F P Luiken; Theo H M Roemen; Ger J Van der Vusse
Journal:  Biochem J       Date:  2003-05-01       Impact factor: 3.857

4.  Characterization of a new fatty acid response element that controls the expression of the locust muscle FABP gene.

Authors:  Qiwei Wu; Weihua Chang; Jutta Rickers-Haunerland; Tobi Higo; Norbert H Haunerland
Journal:  Mol Cell Biochem       Date:  2002-10       Impact factor: 3.396

Review 5.  Metabolic cardiomyopathies.

Authors:  B Guertl; C Noehammer; G Hoefler
Journal:  Int J Exp Pathol       Date:  2000-12       Impact factor: 1.925

6.  Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic rat.

Authors:  W Engels; M van Bilsen; B H Wolffenbuttel; G J van der Vusse; J F Glatz
Journal:  Mol Cell Biochem       Date:  1999-02       Impact factor: 3.396

Review 7.  Fatty acid-binding proteins in the heart.

Authors:  F G Schaap; G J van der Vusse; J F Glatz
Journal:  Mol Cell Biochem       Date:  1998-03       Impact factor: 3.396

8.  Membrane-associated and cytoplasmic fatty acid-binding proteins.

Authors:  F A Van Nieuwenhoven; G J Van der Vusse; J F Glatz
Journal:  Lipids       Date:  1996-03       Impact factor: 1.880

9.  Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet.

Authors:  D E Greenwalt; S H Scheck; T Rhinehart-Jones
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

10.  Novel remodeling of the mouse heart mitochondrial proteome in response to acute insulin stimulation.

Authors:  B A Pedersen; P G Yazdi; J F Taylor; O S Khattab; Y-H Chen; Y Chen; P H Wang
Journal:  Nutr Metab Cardiovasc Dis       Date:  2015-10-22       Impact factor: 4.222
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.