Literature DB >> 8134418

Cytotoxic terpenoids and flavonoids from Artemisia annua.

G Q Zheng1.   

Abstract

The cytotoxic activity of nine terpenoids and flavonoids isolated from Artemisia annua was tested in vitro on several human tumor cell lines. These compounds are artemisinin, deoxyartemisinin, artemisinic acid, arteannuin-B, stigmasterol, friedelin, friedelan-3 beta-ol, artemetin, and quercetagetin 6,7,3',4'-tetramethyl ether. Friedelane-type triterpenoids were isolated for the first time from this plant. Artemisinin and quercetagetin 6,7,3',4'-tetramethyl ether showed significant cytotoxicity against P-388, A-549, HT-29, MCF-7, and KB tumor cells.

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Year:  1994        PMID： 8134418     DOI： 10.1055/s-2006-959408

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  17 in total

Review 1.  The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

Authors:  Geoffrey D Brown
Journal:  Molecules       Date:  2010-10-28       Impact factor: 4.411

2.  Effects of astragali radix on the growth of different cancer cell lines.

Authors:  Jiang Lin; Hui-Fang Dong; J J Oppenheim; O M Howard
Journal:  World J Gastroenterol       Date:  2003-04       Impact factor: 5.742

3.  Trichome differentiation on leaf primordia of Helianthus annuus (Asteraceae): morphology, gene expression and metabolite profile.

Authors:  Anna-Katharina Aschenbrenner; Evelyn Amrehn; Lisa Bechtel; Otmar Spring
Journal:  Planta       Date:  2014-12-17       Impact factor: 4.116

4.  5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl-perhydro-3,12-ep-oxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymeth-yl}benzene-1,3-diol.

Authors:  Waseem Gul; Paulo Carvalho; Ahmed Galal; Mitchell A Avery; Mahmoud A El Sohly
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-23

5.  Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice.

Authors:  Kyung Eun Kim; Keon-Hee Ko; Rok Won Heo; Chin-ok Yi; Hyun Joo Shin; Jun Young Kim; Jae-Ho Park; Sanghae Nam; Hwajin Kim; Gu Seob Roh
Journal:  J Med Food       Date:  2016-01-07       Impact factor: 2.786

Review 6.  Progress in the research of artemisinin-related antimalarials: an update.

Authors:  H J Woerdenbag; N Pras; W van Uden; T E Wallaart; A C Beekman; C B Lugt
Journal:  Pharm World Sci       Date:  1994-08-05

7.  Preliminary Case Series of Artemisinin for Prostate Cancer in a Naturopathic Practice.

Authors:  Eric Yarnell
Journal:  J Restor Med       Date:  2015-12-01

8.  Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.

Authors:  Netsanet Worku; Andualem Mossie; August Stich; Arwid Daugschies; Susanne Trettner; Nasr Y A Hemdan; Gerd Birkenmeier
Journal:  ISRN Biochem       Date:  2013-09-22

9.  Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua.

Authors:  Elmar Breuer; Thomas Efferth
Journal:  Nat Prod Bioprospect       Date:  2014-04-12

10.  Protective effect of Artemisia annua L. extract against galactose-induced oxidative stress in mice.

Authors:  Mi Hye Kim; Ji Yeon Seo; Kwang Hyun Liu; Jong-Sang Kim
Journal:  PLoS One       Date:  2014-07-02       Impact factor: 3.240
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