Literature DB >> 8133653

Andrographolide protects rat hepatocytes against paracetamol-induced damage.

P K Visen1, B Shukla, G K Patnaik, B N Dhawan.   

Abstract

Andrographolide, the active constituent isolated from the plant Andrographis paniculata, showed a significant dose dependent (0.75-12 mg/kg p.o. x 7) protective activity against paracetamol-induced toxicity on ex vivo preparation of isolated rat hepatocytes. It significantly increased the percent viability of the hepatocytes as tested by trypan blue exclusion and oxygen uptake tests. It completely antagonized the toxic effects of paracetamol on certain enzymes (GOT, GPT and alkaline phosphatase) in serum as well as in isolated hepatic cells. Andrographolide was found to be more potent than silymarin, a standard hepatoprotective agent.

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Year:  1993        PMID： 8133653     DOI： 10.1016/0378-8741(93)90058-d

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  23 in total

1.  Protective effect of andrographolide against concanavalin A-induced liver injury.

Authors:  Guojun Shi; Zhijian Zhang; Rong Zhang; Xiaofang Zhang; Yan Lu; Jian Yang; Di Zhang; Zhiguo Zhang; Xiaoying Li; Guang Ning
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-09-24       Impact factor: 3.000

2.  14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway.

Authors:  D N Roy; S Mandal; G Sen; S Mukhopadhyay; T Biswas
Journal:  Br J Pharmacol       Date:  2010-08       Impact factor: 8.739

3.  Survey and scientific evaluation of medicinal plants used by the Pahan and Teli tribal communities of Natore district, Bangladesh.

Authors:  Mohammed Rahmatullah; Zubaida Khatun; Abid Hasan; Waheda Parvin; Md Moniruzzaman; Asha Khatun; Mostafi Jumrut Mahal; Md Shaiful Alam Bhuiyan; Sadia Moin Mou; Rownak Jahan
Journal:  Afr J Tradit Complement Altern Med       Date:  2012-04-02

4.  Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells.

Authors:  María A Hidalgo; Alex Romero; Jaime Figueroa; Patricia Cortés; Ilona I Concha; Juan L Hancke; Rafael A Burgos
Journal:  Br J Pharmacol       Date:  2005-03       Impact factor: 8.739

Review 5.  Medicinal plants and cancer chemoprevention.

Authors:  Avni G Desai; Ghulam N Qazi; Ramesh K Ganju; Mahmoud El-Tamer; Jaswant Singh; Ajit K Saxena; Yashbir S Bedi; Subhash C Taneja; Hari K Bhat
Journal:  Curr Drug Metab       Date:  2008-09       Impact factor: 3.731

6.  Engineered andrographolide nanoparticles mitigate paracetamol hepatotoxicity in mice.

Authors:  Partha Roy; Suvadra Das; Runa Ghosh Auddy; Achintya Saha; Arup Mukherjee
Journal:  Pharm Res       Date:  2013-01-15       Impact factor: 4.200

7.  Therapeutic Potential of Plants as Anti-microbials for Drug Discovery.

Authors:  Ramar Perumal Samy; Ponnampalam Gopalakrishnakone
Journal:  Evid Based Complement Alternat Med       Date:  2008-06-24       Impact factor: 2.629

8.  Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.

Authors:  Ke Yang; Ke Wu; Jianguo Feng; Ling Yutian; Xin Zhu; Dong Xu
Journal:  Evid Based Complement Alternat Med       Date:  2021-07-14       Impact factor: 2.629

9.  Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.

Authors:  Thanasekaran Jayakumar; Cheng-Ying Hsieh; Jie-Jen Lee; Joen-Rong Sheu
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-24       Impact factor: 2.629

10.  Safety assessment of zigbir®: a polyherbal formulation in sprague-dawley rats.

Authors:  Joseph Joshua Allan; Ranjit Madhukar Bhide; Amit Agarwal
Journal:  J Toxicol       Date:  2012-10-18
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