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Literature DB >> 8133500

Presymptomatic testing for Huntington's disease: a world wide survey. The World Federation of Neurology Research Group on Huntington's Disease.

Abstract

World wide data on presymptomatic testing for Huntington's disease using closely linked DNA markers show that 1479 persons at risk received completed test results up to the end of 1991. Testing has been carried out in 19 countries, with at least 88 centres involved, and numbers have levelled off after a peak in 1990. Only 5% of those at risk have been tested in six countries with the longest established programmes. Continued monitoring of international data will be of value in assessing the spread and impact of genetic testing, not only for Huntington's disease, but for other serious genetic disorders of later life.

Entities: Disease Species

Mesh：

Substances：
Genetic Markers

Year: 1993 PMID： 8133500 PMCID： PMC1016637 DOI： 10.1136/jmg.30.12.1020

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

10 in total

1. Problems in genetic prediction for Huntington's disease.

Authors: M J Morris; A Tyler; L Lazarou; L Meredith; P S Harper
Journal: Lancet Date: 1989-09-09 Impact factor: 79.321

2. Huntington disease: no evidence for locus heterogeneity.

Authors: P M Conneally; J L Haines; R E Tanzi; N S Wexler; G K Penchaszadeh; P S Harper; S E Folstein; J J Cassiman; R H Myers; A B Young
Journal: Genomics Date: 1989-08 Impact factor: 5.736

3. A polymorphic DNA marker genetically linked to Huntington's disease.

Authors: J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal: Nature Date: 1983 Nov 17-23 Impact factor: 49.962

Review 4. Huntington disease: genetics and epidemiology.

Authors: P M Conneally
Journal: Am J Hum Genet Date: 1984-05 Impact factor: 11.025

5. Presymptomatic testing for Huntington's disease in the United Kingdom. The United Kingdom Huntington's Disease Prediction Consortium.

Authors: A Tyler; D Ball; D Craufurd
Journal: BMJ Date: 1992-06-20

6. Predictive testing for Huntington disease in Canada: the experience of those receiving an increased risk.

Authors: M Bloch; S Adam; S Wiggins; M Huggins; M R Hayden
Journal: Am J Med Genet Date: 1992-02-15

7. Predictive testing for Huntington's disease with use of a linked DNA marker.

Authors: G J Meissen; R H Myers; C A Mastromauro; W J Koroshetz; K W Klinger; L A Farrer; P A Watkins; J F Gusella; E D Bird; J B Martin
Journal: N Engl J Med Date: 1988-03-03 Impact factor: 91.245

8. A highly polymorphic locus very tightly linked to the Huntington's disease gene.

Authors: J J Wasmuth; J Hewitt; B Smith; D Allard; J L Haines; D Skarecky; E Partlow; M R Hayden
Journal: Nature Date: 1988-04-21 Impact factor: 49.962

9. Presymptomatic diagnosis of delayed-onset disease with linked DNA markers. The experience in Huntington's disease.

Authors: J Brandt; K A Quaid; S E Folstein; P Garber; N E Maestri; M H Abbott; P R Slavney; M L Franz; L Kasch; H H Kazazian
Journal: JAMA Date: 1989-06-02 Impact factor: 56.272

10. Predictive testing for Huntington disease: I. Description of a pilot project in British Columbia.

Authors: S Fox; M Bloch; M Fahy; M R Hayden
Journal: Am J Med Genet Date: 1989-02