Literature DB >> 8133105

A rapid screen test for in vitro susceptibility of clinical herpes simplex virus isolates.

S Safrin1, T Elbeik, J Mills.   

Abstract

A rapid screening test for antiviral susceptibility to acyclovir and foscarnet was evaluated in 320 herpes simplex virus (HSV) isolates from 197 patients. Of the isolates tested (16% HSV-1, 84% HSV-2), 60% were resistant in vitro to acyclovir and 5% were resistant to foscarnet using the plaque reduction assay. The rapid screening test, requiring only 3 days to yield a preliminary susceptibility result, was highly associated with the results of the plaque reduction assay for acyclovir and foscarnet (P < or = .001 for each) and with the clinical response to antiviral therapy (P < .001, P = .001, respectively).

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Year:  1994        PMID： 8133105     DOI： 10.1093/infdis/169.4.879

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  5 in total

1.  Use of a single monoclonal antibody to determine the susceptibilities of herpes simplex virus type 1 and type 2 clinical isolates to acyclovir.

Authors:  Christine Chutkowski; Betty Olson; Ann McDonough; James Mahoney; James J McSharry
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

2.  Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.

Authors:  P Tebas; E C Stabell; P D Olivo
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

3.  Application of real-time PCR for determination of antiviral drug susceptibility of herpes simplex virus.

Authors:  Růzena Stránská; Anton M van Loon; Merjo Polman; Rob Schuurman
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

4.  A Novel Method to Titrate Herpes Simplex Virus-1 (HSV-1) Using Laser-Based Scanning of Near-Infrared Fluorophores Conjugated Antibodies.

Authors:  Marco Fabiani; Dolores Limongi; Anna Teresa Palamara; Giovanna De Chiara; Maria Elena Marcocci
Journal:  Front Microbiol       Date:  2017-06-14       Impact factor: 5.640

5.  Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses.

Authors:  Rosa Giugliano; Carmine Buonocore; Carla Zannella; Annalisa Chianese; Fortunato Palma Esposito; Pietro Tedesco; Anna De Filippis; Massimiliano Galdiero; Gianluigi Franci; Donatella de Pascale
Journal:  Pharmaceutics       Date:  2021-12-08       Impact factor: 6.321
  5 in total

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