Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Targeting of c-myc and beta-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3' untranslated region.

Literature DB >> 8129712

Targeting of c-myc and beta-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3' untranslated region.

J Hesketh¹, G Campbell, M Piechaczyk, J M Blanchard.

Abstract

The influence of the 3' untranslated region on mRNA localization was investigated by measuring the distribution of myc, beta-globin and hybrid myc-globin mRNAs between free, cytoskeletal-bound and membrane-bound polysomes in cells transfected with either control or chimeric gene constructs. c-myc sequences and beta-globin-coding sequences linked to the myc 3' untranslated region were present at greatest enrichment in cytoskeletal-bound polysomes. beta-Globin mRNA and myc-coding sequences linked to the beta-globin 3' untranslated region were recovered largely in the free polysomes. In situ hybridization confirmed that replacement of the c-myc 3' untranslated region by that of globin caused a relocalization of the mRNA. The results suggest that mRNA localization in differentiated eukaryotic cells depends on a mechanism that involves directional information in the 3' untranslated region of mRNAs.

Entities: Gene

Mesh：

Substances：
RNA, Messenger
Globins

Year: 1994 PMID： 8129712 PMCID： PMC1137994 DOI： 10.1042/bj2980143

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. Cytoskeleton involvement in the distribution of mRNP complexes and small cytoplasmic RNAs.

Authors: R C Bird; B H Sells
Journal: Biochim Biophys Acta Date: 1986-12-18

2. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors: P Chomczynski; N Sacchi
Journal: Anal Biochem Date: 1987-04 Impact factor: 3.365

3. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.

Authors: D L Weeks; D A Melton
Journal: Cell Date: 1987-12-04 Impact factor: 41.582

4. The material mRNA Vg1 is correctly localized following injection into Xenopus oocytes.

Authors: J K Yisraeli; D A Melton
Journal: Nature Date: 1988-12-08 Impact factor: 49.962

5. Sequence determinants of c-myc mRNA turn-over: influence of 3' and 5' non-coding regions.

Authors: A Bonnieu; M Piechaczyk; L Marty; M Cuny; J M Blanchard; P Fort; P Jeanteur
Journal: Oncogene Res Date: 1988-09

6. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Authors: H Land; L F Parada; R A Weinberg
Journal: Nature Date: 1983 Aug 18-24 Impact factor: 49.962

7. The density of HLA-DR antigen expression on alveolar macrophages is increased in pulmonary sarcoidosis.

Authors: D A Campbell; R M du Bois; R G Butcher; L W Poulter
Journal: Clin Exp Immunol Date: 1986-07 Impact factor: 4.330

8. cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos.

Authors: P M Macdonald; G Struhl
Journal: Nature Date: 1988-12-08 Impact factor: 49.962

9. Localized maternal mRNA related to transforming growth factor beta mRNA is concentrated in a cytokeratin-enriched fraction from Xenopus oocytes.

Authors: M D Pondel; M L King
Journal: Proc Natl Acad Sci U S A Date: 1988-10 Impact factor: 11.205

10. Intracellular localization of messenger RNAs for cytoskeletal proteins.

Authors: J B Lawrence; R H Singer
Journal: Cell Date: 1986-05-09 Impact factor: 41.582

14 in total

1. Influence of metallothionein-1 localization on its function.

Authors: M Levadoux-Martin; J E Hesketh; J H Beattie; H M Wallace
Journal: Biochem J Date: 2001-04-15 Impact factor: 3.857

2. An AU-rich stem-loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA.

Authors: Hervé Chabanon; Ian Mickleburgh; Brian Burtle; Christopher Pedder; John Hesketh
Journal: Biochem J Date: 2005-12-15 Impact factor: 3.857

3. Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.

Authors: B M Davis; M E McCurrach; K L Taneja; R H Singer; D E Housman
Journal: Proc Natl Acad Sci U S A Date: 1997-07-08 Impact factor: 11.205

4. Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop.

Authors: Ian Mickleburgh; Hervé Chabanon; David Nury; Kunbo Fan; Brian Burtle; Zofia Chrzanowska-Lightowlers; John Hesketh
Journal: RNA Date: 2006-05-24 Impact factor: 4.942

5. Competition between the signal sequence and a 3'UTR localisation signal during redirection of beta-globin mRNA to the endoplasmic reticulum: implications for biotechnology.

Authors: K A Partridge; A Johannessen; A Tauler; I F Pryme; J E Hesketh
Journal: Cytotechnology Date: 1999-07 Impact factor: 2.058

6. The mRNAs for cyclin A, c-myc and ribosomal proteins L4 and S6 are associated with cytoskeletal-bound polysomes in HepG2 cells.

Authors: R Hovland; G Campbell; I Pryme; J Hesketh
Journal: Biochem J Date: 1995-08-15 Impact factor: 3.857

Review 7. mRNA stability in mammalian cells.

Authors: J Ross
Journal: Microbiol Rev Date: 1995-09