| Literature DB >> 8128250 |
W R Engels1, C R Preston, D M Johnson-Schlitz.
Abstract
P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.Entities:
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Year: 1994 PMID： 8128250 DOI： 10.1126/science.8128250
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728