Literature DB >> 8126692

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.

H G Beaton1, C Bennion, S Connolly, A R Cook, N P Gensmantel, C Hallam, K Hardy, B Hitchin, C G Jackson, D H Robinson.   

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Year:  1994        PMID： 8126692     DOI： 10.1021/jm00031a001

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  7 in total

Review 1.  Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

Authors:  Edward A Dennis; Jian Cao; Yuan-Hao Hsu; Victoria Magrioti; George Kokotos
Journal:  Chem Rev       Date:  2011-09-12       Impact factor: 60.622

2.  The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding.

Authors:  Brian P Smart; Rob C Oslund; Laura A Walsh; Michael H Gelb
Journal:  J Med Chem       Date:  2006-05-18       Impact factor: 7.446

3.  Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor.

Authors:  Varnavas D Mouchlis; Thomas M Mavromoustakos; George Kokotos
Journal:  J Comput Aided Mol Des       Date:  2010-02-04       Impact factor: 3.686

4.  Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes.

Authors:  Georgia Antonopoulou; Efrosini Barbayianni; Victoria Magrioti; Naomi Cotton; Daren Stephens; Violetta Constantinou-Kokotou; Edward A Dennis; George Kokotos
Journal:  Bioorg Med Chem       Date:  2008-11-01       Impact factor: 3.641

5.  Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations.

Authors:  Sofia Vasilakaki; Efrosini Barbayianni; Georgios Leonis; Manthos G Papadopoulos; Thomas Mavromoustakos; Michael H Gelb; George Kokotos
Journal:  Bioorg Med Chem       Date:  2016-03-02       Impact factor: 3.641

6.  Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.

Authors:  R W Schevitz; N J Bach; D G Carlson; N Y Chirgadze; D K Clawson; R D Dillard; S E Draheim; L W Hartley; N D Jones; E D Mihelich
Journal:  Nat Struct Biol       Date:  1995-06

Review 7.  pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics.

Authors:  Vittorio Caprio; Lina Badimon; Mario Di Napoli; Wen-Hui Fang; Glenn R Ferris; Baoqiang Guo; Rocco S Iemma; Donghui Liu; Yasmin Zeinolabediny; Mark Slevin
Journal:  Front Immunol       Date:  2018-05-28       Impact factor: 7.561
  7 in total

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