Literature DB >> 8120016

Increase of Na/Pi-cotransport encoding mRNA in response to low Pi diet in rat kidney cortex.

A Werner1, S A Kempson, J Biber, H Murer.   

Abstract

Renal proximal Na/Pi-cotransport is increased in response to low dietary Pi intake. Recently, a cDNA (NaPi-2) related to the rat renal brush membrane Na/Pi-cotransporter has been cloned. In the present study, we used rats fed for 6 days with either a low Pi diet (LPD) or a high Pi diet (HPD), respectively. In parallel to an increased renal brush-border membrane Na/Pi-cotransport in LPD rats, there was also an increased content of NaPi-2 mRNA in renal cortex. After injection into Xenopus laevis oocytes, mRNA isolated from LPD rats induced a greater increase in Na/Pi-cotransport compared to mRNA from HPD rats. Hybrid depletion experiments suggested that mRNA-induced Na/Pi-cotransport is related to NaPi-2. We conclude that chronic Pi deprivation leads to an increased brush-border membrane Na/Pi-cotransport via an increase in the level of (NaPi-2) mRNA.

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Year:  1994        PMID： 8120016

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  14 in total

1.  Effects of Npt2 gene ablation and low-phosphate diet on renal Na(+)/phosphate cotransport and cotransporter gene expression.

Authors:  H M Hoag; J Martel; C Gauthier; H S Tenenhouse
Journal:  J Clin Invest       Date:  1999-09       Impact factor: 14.808

2.  Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells.

Authors:  Theresa J Berndt; Bernhard Bielesz; Theodore A Craig; Peter J Tebben; Desa Bacic; Carsten A Wagner; Stephen O'Brien; Susan Schiavi; Jurg Biber; Heini Murer; Rajiv Kumar
Journal:  Pflugers Arch       Date:  2005-09-09       Impact factor: 3.657

3.  Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression.

Authors:  K Miyamoto; S Tatsumi; T Sonoda; H Yamamoto; H Minami; Y Taketani; E Takeda
Journal:  Biochem J       Date:  1995-01-01       Impact factor: 3.857

4.  Functional expression of rat renal Na/Pi-cotransport (NaPi-2) in Sf9 cells by the baculovirus system.

Authors:  M Fucentese; K Winterhalter; H Murer; J Biber
Journal:  J Membr Biol       Date:  1995-03       Impact factor: 1.843

5.  Involvement of disulphide bonds in the renal sodium/phosphate co-transporter NaPi-2.

Authors:  Y Xiao; C J Boyer; E Vincent; A Dugré; V Vachon; M Potier; R Béliveau
Journal:  Biochem J       Date:  1997-04-15       Impact factor: 3.857

6.  Thyroid hormone stimulation of Na/Pi-cotransport in opossum kidney cells.

Authors:  V Sorribas; D Markovich; T Verri; J Biber; H Murer
Journal:  Pflugers Arch       Date:  1995-12       Impact factor: 3.657

7.  Transport characteristics of a murine renal Na/Pi-cotransporter.

Authors:  C M Hartmann; C A Wagner; A E Busch; D Markovich; J Biber; F Lang; H Murer
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

8.  Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate.

Authors:  Mikiko Ito; Sachi Iidawa; Michiyo Izuka; Sakiko Haito; Hiroko Segawa; Masashi Kuwahata; Ichiro Ohkido; Hiroshi Ohno; Ken-Ichi Miyamoto
Journal:  Biochem J       Date:  2004-02-01       Impact factor: 3.857

9.  Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.

Authors:  A E Busch; A Schuster; S Waldegger; C A Wagner; G Zempel; S Broer; J Biber; H Murer; F Lang
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

10.  In vivo suppression of the renal Na+/Pi cotransporter by antisense oligonucleotides.

Authors:  R Oberbauer; G F Schreiner; J Biber; H Murer; T W Meyer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205
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