Literature DB >> 8118424

Synthesis and characterization of oligonucleotides containing the alpha-anomer of deoxyadenosine to study its influence on DNA replication.

H Ide1, M Okagami, H Murayama, Y Kimura, K Makino.   

Abstract

The alpha-anomer of 2'-deoxyadenosine 1 is a major adenine lesion produced by hydroxyl radicals in DNA. To assess its biochemical effects on DNA replication, 1 was site-specifically incorporated into oligonucleotide templates using phosphoramidite chemistry. The templates were purified and extensively characterized to ensure their homogeneity and nucleotide sequences.

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Year:  1993        PMID： 8118424

Source DB:  PubMed          Journal:  Biochem Mol Biol Int        ISSN： 1039-9712


  5 in total

1.  Novel repair activities of AlkA (3-methyladenine DNA glycosylase II) and endonuclease VIII for xanthine and oxanine, guanine lesions induced by nitric oxide and nitrous acid.

Authors:  Hiroaki Terato; Aya Masaoka; Kenjiro Asagoshi; Akiko Honsho; Yoshihiko Ohyama; Toshinori Suzuki; Masaki Yamada; Keisuke Makino; Kazuo Yamamoto; Hiroshi Ide
Journal:  Nucleic Acids Res       Date:  2002-11-15       Impact factor: 16.971

2.  Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vectors.

Authors:  H Shimizu; R Yagi; Y Kimura; K Makino; H Terato; Y Ohyama; H Ide
Journal:  Nucleic Acids Res       Date:  1997-02-01       Impact factor: 16.971

3.  On the mechanism of preferential incorporation of dAMP at abasic sites in translesional DNA synthesis. Role of proofreading activity of DNA polymerase and thermodynamic characterization of model template-primers containing an abasic site.

Authors:  H Ide; H Murayama; S Sakamoto; K Makino; K Honda; H Nakamuta; M Sasaki; N Sugimoto
Journal:  Nucleic Acids Res       Date:  1995-01-11       Impact factor: 16.971

Review 4.  Ribonucleotides in bacterial DNA.

Authors:  Jeremy W Schroeder; Justin R Randall; Lindsay A Matthews; Lyle A Simmons
Journal:  Crit Rev Biochem Mol Biol       Date:  2014-11-12       Impact factor: 8.250

5.  Substrate and mispairing properties of 5-formyl-2'-deoxyuridine 5'-triphosphate assessed by in vitro DNA polymerase reactions.

Authors:  M Yoshida; K Makino; H Morita; H Terato; Y Ohyama; H Ide
Journal:  Nucleic Acids Res       Date:  1997-04-15       Impact factor: 16.971
  5 in total

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