Literature DB >> 811799

Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.

G R Revanker, T R Matthews, R K Robins.   

Abstract

A series of 5-substituted and 5,7-disubstituted imidazo[1,2-a]pyrimidines has been prepared. The in vitro antimicrobial activity of these compounds against a variety of microorganisms is reported. 5-n-Octylaminoimidazo[1,2-a]pyrimidine exhibited significant activity against all the microorganisms studied.

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Year:  1975        PMID： 811799     DOI： 10.1021/jm00246a018

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Chemically defined medium for susceptibility testing of antimicrobial agents.

Authors:  P F Dougherty; D L Yotter; T R Matthews
Journal:  Antimicrob Agents Chemother       Date:  1976-12       Impact factor: 5.191

2.  One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Authors:  Zhang-Gao Le; Zong-Bo Xie; Jian-Ping Xu
Journal:  Molecules       Date:  2012-11-09       Impact factor: 4.411

3.  2-Methyl-6-(trifluoro-meth-yl)imidazo[1,2-a]pyridine-3-carbonitrile.

Authors:  Hoong-Kun Fun; Mohd Mustaqim Rosli; D J Madhu Kumar; D Jagadeesh Prasad; G K Nagaraja
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-02-05

4.  Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Authors:  Lisa Yu; Andres Lopez; Abderrahmane Anaflous; Brahim El Bali; Abdellah Hamal; Elke Ericson; Lawrence E Heisler; Angus McQuibban; Guri Giaever; Corey Nislow; Charles Boone; Grant W Brown; Mohammed Bellaoui
Journal:  PLoS Genet       Date:  2008-11-28       Impact factor: 5.917

5.  Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

Authors:  Christopher R Coxon; Elizabeth Anscombe; Suzannah J Harnor; Mathew P Martin; Benoit Carbain; Bernard T Golding; Ian R Hardcastle; Lisa K Harlow; Svitlana Korolchuk; Christopher J Matheson; David R Newell; Martin E M Noble; Mangaleswaran Sivaprakasam; Susan J Tudhope; David M Turner; Lan Z Wang; Stephen R Wedge; Christopher Wong; Roger J Griffin; Jane A Endicott; Céline Cano
Journal:  J Med Chem       Date:  2017-02-14       Impact factor: 7.446
  5 in total

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