Literature DB >> 8115163

Peptide nucleic acid (PNA): a model structure for the primordial genetic material?

P E Nielsen1.   

Abstract

It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA monomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

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Year:  1993        PMID： 8115163     DOI： 10.1007/bf01582083

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN： 0169-6149            Impact factor:   1.950


  14 in total

1.  Genetical implications of the structure of deoxyribonucleic acid.

Authors:  J D WATSON; F H CRICK
Journal:  Nature       Date:  1953-05-30       Impact factor: 49.962

2.  Unusual resistance of peptidyl transferase to protein extraction procedures.

Authors:  H F Noller; V Hoffarth; L Zimniak
Journal:  Science       Date:  1992-06-05       Impact factor: 47.728

3.  Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation.

Authors:  J T Wong
Journal:  Orig Life Evol Biosph       Date:  1991       Impact factor: 1.950

4.  A model for the RNA-catalyzed replication of RNA.

Authors:  T R Cech
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

Review 5.  Evolution of the genetic apparatus: a review.

Authors:  L E Orgel
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1987

6.  Prebiotic synthesis: problems and challenges.

Authors:  J P Ferris
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1987

7.  The case for an ancestral genetic system involving simple analogues of the nucleotides.

Authors:  G F Joyce; A W Schwartz; S L Miller; L E Orgel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

8.  Which organic compounds could have occurred on the prebiotic earth?

Authors:  S L Miller
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1987

9.  A possible role of fluctuating clay-water systems in the production of ordered prebiotic oligomers.

Authors:  N Lahav; D H White
Journal:  J Mol Evol       Date:  1980-09       Impact factor: 2.395

10.  Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Science       Date:  1991-12-06       Impact factor: 47.728
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  20 in total

Review 1.  PNA Technology.

Authors:  Peter E Nielsen
Journal:  Mol Biotechnol       Date:  2004-03       Impact factor: 2.695

2.  Proto-organism kinetics: evolutionary dynamics of lipid aggregates with genes and metabolism.

Authors:  Steen J Rasmussen; Liaohai Chen; Bärbel M R Stadler; Peter F Stadler
Journal:  Orig Life Evol Biosph       Date:  2004-02       Impact factor: 1.950

Review 3.  The role of natural selection in the origin of life.

Authors:  Iris Fry
Journal:  Orig Life Evol Biosph       Date:  2010-04-21       Impact factor: 1.950

4.  Homochiral growth through enantiomeric cross-inhibition.

Authors:  A Brandenburg; A C Andersen; S Höfner; M Nilsson
Journal:  Orig Life Evol Biosph       Date:  2005-06       Impact factor: 1.950

5.  Surfactant assemblies and their various possible roles for the origin(s) of life.

Authors:  Peter Walde
Journal:  Orig Life Evol Biosph       Date:  2006-04-27       Impact factor: 1.950

6.  Prebiotic materials from on and off the early Earth.

Authors:  Max Bernstein
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-10-29       Impact factor: 6.237

7.  From volcanic origins of chemoautotrophic life to Bacteria, Archaea and Eukarya.

Authors:  Günter Wächtershäuser
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-10-29       Impact factor: 6.237

8.  Prebiotic cytosine synthesis: a critical analysis and implications for the origin of life.

Authors:  R Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

9.  Modulation of adenosine 5'-monophosphate adsorption onto aqueous resident pyrite: potential mechanisms for prebiotic reactions.

Authors:  M Pontes-Buarques; A C Tessis; J A Bonapace; M B Monte; G Cortés-Lopez; F De Souza-Barros; A Vieyra
Journal:  Orig Life Evol Biosph       Date:  2001 Aug-Oct       Impact factor: 1.950

10.  Identification of diamino acids in the Murchison meteorite.

Authors:  Uwe J Meierhenrich; Guillermo M Muñoz Caro; Jan Hendrik Bredehöft; Elmar K Jessberger; Wolfram H-P Thiemann
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-11       Impact factor: 11.205
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