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Literature DB >> 15004293

PNA Technology.

Abstract

Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine, including drug discovery, genetic diagnostics, molecular recognition, and the origin of life. Recent progress in studies of PNA properties and applications is reviewed.

Mesh：

Substances：

Year: 2004 PMID： 15004293 DOI： 10.1385/MB:26:3:233

Source DB: PubMed Journal: Mol Biotechnol ISSN： 1073-6085 Impact factor: 2.695

126 in total

1. Peptide nucleic acid-mediated PCR clamping as a useful supplement in the determination of microbial diversity.

Authors: F von Wintzingerode; O Landt; A Ehrlich; U B Göbel
Journal: Appl Environ Microbiol Date: 2000-02 Impact factor: 4.792

2. Combination of ATP-bioluminescence and PNA probes allows rapid total counts and identification of specific microorganisms in mixed populations.

Authors: H Stender; A Sage; K Oliveira; A J Broomer; B Young; J Coull
Journal: J Microbiol Methods Date: 2001-07-30 Impact factor: 2.363

3. PNA beacons for duplex DNA.

Authors: H Kuhn; V V Demidov; B D Gildea; M J Fiandaca; J C Coull; M D Frank-Kamenetskii
Journal: Antisense Nucleic Acid Drug Dev Date: 2001-08

4. Detection of genetic point mutations by peptide nucleic acid-mediated polymerase chain reaction clamping using paraffin-embedded specimens.

Authors: Y Myal; A Blanchard; P Watson; M Corrin; R Shiu; B Iwasiow
Journal: Anal Biochem Date: 2000-10-01 Impact factor: 3.365

5. Polyclonal hematopoiesis with variable telomere shortening in human long-term allogeneic marrow graft recipients.

Authors: G Mathioudakis; R Storb; P A McSweeney; B Torok-Storb; P M Lansdorp; T H Brümmendorf; M J Gass; E M Bryant; J Storek; M E Flowers; T Gooley; R A Nash
Journal: Blood Date: 2000-12-01 Impact factor: 22.113

Review 6. Peptide nucleic acid: a versatile tool in genetic diagnostics and molecular biology.

Authors: P E Nielsen
Journal: Curr Opin Biotechnol Date: 2001-02 Impact factor: 9.740

7. Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development.

Authors: S H Kang; M J Cho; R Kole
Journal: Biochemistry Date: 1998-05-05 Impact factor: 3.162

8. Sequence specific inhibition of DNA restriction enzyme cleavage by PNA.

Authors: P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal: Nucleic Acids Res Date: 1993-01-25 Impact factor: 16.971

9. Gene delivery by a steroid-peptide nucleic acid conjugate.

Authors: Alexandre G Rebuffat; Andrea R Nawrocki; Peter E Nielsen; Alessio G Bernasconi; Eloy Bernal-Mendez; Brigitte M Frey; Felix J Frey
Journal: FASEB J Date: 2002-07-01 Impact factor: 5.191

10. Information transfer from peptide nucleic acids to RNA by template-directed syntheses.

Authors: J G Schmidt; P E Nielsen; L E Orgel
Journal: Nucleic Acids Res Date: 1997-12-01 Impact factor: 16.971

55 in total

1. Dual peptide nucleic acid- and peptide-functionalized shell cross-linked nanoparticles designed to target mRNA toward the diagnosis and treatment of acute lung injury.

Authors: Ritu Shrestha; Yuefei Shen; Kevin A Pollack; John-Stephen A Taylor; Karen L Wooley
Journal: Bioconjug Chem Date: 2012-02-28 Impact factor: 4.774

2. From Never Born Proteins to Minimal Living Cells: two projects in synthetic biology.

Authors: Pier Luigi Luisi; Cristiano Chiarabelli; Pasquale Stano
Journal: Orig Life Evol Biosph Date: 2006-12 Impact factor: 1.950

3. Gene-specific effects of antisense phosphorodiamidate morpholino oligomer-peptide conjugates on Escherichia coli and Salmonella enterica serovar typhimurium in pure culture and in tissue culture.

Authors: Lucas D Tilley; Orion S Hine; Jill A Kellogg; Jed N Hassinger; Dwight D Weller; Patrick L Iversen; Bruce L Geller
Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191

4. Targeted gene correction using psoralen, chlorambucil and camptothecin conjugates of triplex forming peptide nucleic acid (PNA).

Authors: Henrik Birkedal; Peter E Nielsen
Journal: Artif DNA PNA XNA Date: 2011-01

Review 10. Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems.

Authors: S D Laufer; T Restle
Journal: Curr Pharm Des Date: 2008 Impact factor: 3.116