Literature DB >> 8106293

Chemical modification of natural human tumor necrosis factor-alpha with polyethylene glycol increases its anti-tumor potency.

Y Tsutsumi1, T Kihira, S Yamamoto, K Kubo, S Nakagawa, M Miyake, Y Horisawa, T Kanamori, H Ikegami, T Mayumi.   

Abstract

Natural human tumor necrosis factor-alpha (TNF-alpha) was chemically modified with an active ester of monomethoxy polyethylene glycol (PEG). The molecular weight of PEG-modified TNF-alpha depended on the reaction time as well as the initial molar ratio of PEG to TNF-alpha. The specific activity of modified TNF-alpha was gradually reduced with increase in the degree of PEG-modification, but the plasma half-life of TNF-alpha was increased by up to 40-fold. Modified TNF-alpha showed approximately 100 times greater anti-tumor potency than unmodified TNF-alpha. Covalent attachment of PEG to TNF-alpha thus increased the bioavailability of TNF-alpha, and may facilitate its potential therapeutic use.

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Year:  1994        PMID： 8106293      PMCID： PMC5919344          DOI： 10.1111/j.1349-7006.1994.tb02879.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  18 in total

1.  Evaluation of recombinant human tumor necrosis factor by scheduled intratumoral administration in mice bearing transplantable tumors.

Authors:  K Tamura; H Aso; T Nakamura; H Hemmi; N Ishida
Journal:  Tohoku J Exp Med       Date:  1989-02       Impact factor: 1.848

2.  Proposal of standardized methods and reference for assaying recombinant human tumor necrosis factor.

Authors:  S Yamazaki; E Onishi; K Enami; K Natori; M Kohase; H Sakamoto; M Tanouchi; H Hayashi
Journal:  Jpn J Med Sci Biol       Date:  1986-06

3.  Important role of serotonin in the antitumor effects of recombinant human tumor necrosis factor-alpha in mice.

Authors:  T Manda; F Nishigaki; J Mori; K Shimomura
Journal:  Cancer Res       Date:  1988-08-01       Impact factor: 12.701

4.  Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

Authors:  N V Katre; M J Knauf; W J Laird
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

5.  Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

Authors:  M J Knauf; D P Bell; P Hirtzer; Z P Luo; J D Young; N V Katre
Journal:  J Biol Chem       Date:  1988-10-15       Impact factor: 5.157

6.  Antitumor activity of a novel chimera tumor necrosis factor (TNF-STH) constructed by connecting rTNF-S with thymosin beta 4 against murine syngeneic tumors.

Authors:  K Noguchi; H Inagawa; Y Tsuji; A Morikawa; D Mizuno; G Soma
Journal:  J Immunother (1991)       Date:  1991-04

7.  Pharmacokinetics of recombinant human granulocyte colony-stimulating factor conjugated to polyethylene glycol in rats.

Authors:  H Tanaka; R Satake-Ishikawa; M Ishikawa; S Matsuki; K Asano
Journal:  Cancer Res       Date:  1991-07-15       Impact factor: 12.701

8.  Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice.

Authors:  K Haranaka; N Satomi; A Sakurai
Journal:  Int J Cancer       Date:  1984-08-15       Impact factor: 7.396

9.  Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates.

Authors:  A Abuchowski; G M Kazo; C R Verhoest; T Van Es; D Kafkewitz; M L Nucci; A T Viau; F F Davis
Journal:  Cancer Biochem Biophys       Date:  1984-06

10.  Immunomodulatory and toxic effects of free and liposome-encapsulated tumor necrosis factor alpha in rats.

Authors:  R J Debs; H J Fuchs; R Philip; E N Brunette; N Düzgüneş; J E Shellito; D Liggitt; J R Patton
Journal:  Cancer Res       Date:  1990-01-15       Impact factor: 12.701
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  5 in total

1.  Development of a novel DDS for site-specific PEGylated proteins.

Authors:  Yasuo Yoshioka; Shin-Ichi Tsunoda; Yasuo Tsutsumi
Journal:  Chem Cent J       Date:  2011-05-12       Impact factor: 4.215

Review 2.  Systemic use of tumor necrosis factor alpha as an anticancer agent.

Authors:  Nicholas J Roberts; Shibin Zhou; Luis A Diaz; Matthias Holdhoff
Journal:  Oncotarget       Date:  2011-10

3.  In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors.

Authors:  Y Tsutsumi; S Tsunoda; Y Kaneda; H Kamada; T Kihira; S Nakagawa; Y Yamamoto; Y Horisawa; T Mayumi
Journal:  Jpn J Cancer Res       Date:  1996-10

4.  Intravenous administration of polyethylene glycol-modified tumor necrosis factor-alpha completely regressed solid tumor in Meth-A murine sarcoma model.

Authors:  Y Tsutsumi; T Kihira; S Tsunoda; K Kubo; M Miyake; T Kanamori; S Nakagawa; T Mayumi
Journal:  Jpn J Cancer Res       Date:  1994-12

5.  Selective enhancement by tumor necrosis factor-alpha of vascular permeability of new blood vessels induced with agarose hydrogel-entrapped Meth-A fibrosarcoma cells.

Authors:  N Okada; Y Kaneda; H Miyamoto; Y Yamamoto; H Mizuguchi; Y Tsutsumi; S Nakagawa; T Mayumi
Journal:  Jpn J Cancer Res       Date:  1996-08
  5 in total

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