Literature DB >> 8104032

Neurobiological investigations into the role of cholecystokinin in panic disorder.

J Bradwejn1.   

Abstract

Cholecystokinin (CCK) is a neurotransmitter found in high density in the brains of mammals. Microiontophoretic studies showing that benzodiazepines selectively antagonized CCK-induced excitation of rat hippocampal neurons have led to the hypothesis that CCK is an anxiogenic peptide. The hypothesis was supported by demonstrations that CCK-tetrapeptide (CCK4) induces panic attacks in humans. This paper reviews phases of investigations which studied the validity of CCK4 as a panicogenic agent and research strategies for the study of panic disorder using CCK4 as an investigative tool.

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Year:  1993        PMID： 8104032      PMCID： PMC1188527     

Source DB:  PubMed          Journal:  J Psychiatry Neurosci        ISSN： 1180-4882            Impact factor:   6.186


  53 in total

1.  Carbon dioxide sensitivity in panic anxiety. Ventilatory and anxiogenic response to carbon dioxide in healthy subjects and patients with panic anxiety before and after alprazolam treatment.

Authors:  S W Woods; D S Charney; J Loke; W K Goodman; D E Redmond; G R Heninger
Journal:  Arch Gen Psychiatry       Date:  1986-09

2.  A cognitive approach to panic.

Authors:  D M Clark
Journal:  Behav Res Ther       Date:  1986

3.  Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit.

Authors:  P Pilowsky; M West; J Chalmers
Journal:  Neurosci Lett       Date:  1985-09-16       Impact factor: 3.046

4.  Fine structural studies of cholecystokinin-8-like immunoreactive neurons and axon terminals in the nucleus of tractus solitarius of the rat.

Authors:  H Takagi; Y Kubota; S Mori; K Tateishi; T Hamaoka; M Tohyama
Journal:  J Comp Neurol       Date:  1984-08-10       Impact factor: 3.215

5.  Two brain cholecystokinin receptors: implications for behavioral actions.

Authors:  T H Moran; P H Robinson; M S Goldrich; P R McHugh
Journal:  Brain Res       Date:  1986-01-01       Impact factor: 3.252

6.  Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurones.

Authors:  J Bradwejn; C de Montigny
Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

Review 7.  Sodium lactate infusions and panic attacks: a review and critique.

Authors:  J Margraf; A Ehlers; W T Roth
Journal:  Psychosom Med       Date:  1986 Jan-Feb       Impact factor: 4.312

8.  Anxiety sensitivity, anxiety frequency and the prediction of fearfulness.

Authors:  S Reiss; R A Peterson; D M Gursky; R J McNally
Journal:  Behav Res Ther       Date:  1986

Review 9.  Adenosine's role in the central actions of the benzodiazepines.

Authors:  J W Phillis
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1984       Impact factor: 5.067

10.  Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-induced activation of hippocampal pyramidal neurons: a microiontophoretic study in the rat.

Authors:  J Bradwejn; C De Montigny
Journal:  Eur J Pharmacol       Date:  1985-06-19       Impact factor: 4.432
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  9 in total

1.  Effect of oral ondansetron on total cholecystokinin plasma levels following CCK-4 panic challenge procedure in healthy men.

Authors:  M Dépôt; S Merani; J Bradwejn; J Mukherjee; J Caillé; J Gutkowska; G Caillé
Journal:  J Psychiatry Neurosci       Date:  1998-11       Impact factor: 6.186

2.  Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes.

Authors:  N Irwin; P Frizelle; I A Montgomery; R C Moffett; F P M O'Harte; P R Flatt
Journal:  Diabetologia       Date:  2012-07-20       Impact factor: 10.122

3.  Distribution of type I corticotropin-releasing factor (CRF1) receptors on GABAergic neurons within the basolateral amygdala.

Authors:  Katina C Calakos; Dakota Blackman; Alexandra M Schulz; Elizabeth P Bauer
Journal:  Synapse       Date:  2017-02-20       Impact factor: 2.562

4.  The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin.

Authors:  Hemin Feng; Junfeng Su; Wei Fang; Xi Chen; Jufang He
Journal:  Elife       Date:  2021-11-15       Impact factor: 8.140

5.  Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice.

Authors:  N Irwin; I A Montgomery; P R Flatt
Journal:  Diabetologia       Date:  2013-03-06       Impact factor: 10.122

Review 6.  Cholecystokinin receptor subtypes: role in the modulation of anxiety-related and reward-related behaviours in animal models.

Authors:  Susan Rotzinger; Franco J Vaccarino
Journal:  J Psychiatry Neurosci       Date:  2003-05       Impact factor: 6.186

Review 7.  Panic disorder. Pathophysiology and drug treatment.

Authors:  M R Johnson; R B Lydiard; J C Ballenger
Journal:  Drugs       Date:  1995-03       Impact factor: 9.546

Review 8.  CCKB/gastrin receptor antagonists: recent advances and potential uses in gastric secretory disorders.

Authors:  R T Jensen
Journal:  Yale J Biol Med       Date:  1996 May-Jun

Review 9.  The Neuromodulatory Basis of Aggression: Lessons From the Humble Fruit Fly.

Authors:  Caroline B Palavicino-Maggio; Saheli Sengupta
Journal:  Front Behav Neurosci       Date:  2022-04-18       Impact factor: 3.617
  9 in total

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