Adenosine's role in the central actions of the benzodiazepines.

The hypothesis that inhibition of adenosine uptake may play an important role in the central actions of the benzodiazepines is presented. The evidence supporting this hypothesis is discussed. Brain concentrations of the benzodiazepines are adequate for inhibition of adenosine uptake. Benzodiazepines, such as RO15-1788 and RO5-4864, which do not enhance gamma-aminobutyric acid binding, may exert some of their central effects by inhibiting the uptake of adenosine.