Literature DB >> 8103804

Congo red inhibition of scrapie agent replication.

B Caughey1, D Ernst, R E Race.   

Abstract

Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.

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Year:  1993        PMID： 8103804      PMCID： PMC238051     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  A cellular gene encodes scrapie PrP 27-30 protein.

Authors:  B Oesch; D Westaway; M Wälchli; M P McKinley; S B Kent; R Aebersold; R A Barry; P Tempst; D B Teplow; L E Hood
Journal:  Cell       Date:  1985-04       Impact factor: 41.582

2.  The reticuloendothelial system in scrapie pathogenesis.

Authors:  B Ehlers; R Rudolph; H Diringer
Journal:  J Gen Virol       Date:  1984-02       Impact factor: 3.891

3.  Antibodies to a scrapie prion protein.

Authors:  P E Bendheim; R A Barry; S J DeArmond; D P Stites; S B Prusiner
Journal:  Nature       Date:  1984 Aug 2-8       Impact factor: 49.962

4.  Scrapie prions aggregate to form amyloid-like birefringent rods.

Authors:  S B Prusiner; M P McKinley; K A Bowman; D C Bolton; P E Bendheim; D F Groth; G G Glenner
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

5.  A protease-resistant protein is a structural component of the scrapie prion.

Authors:  M P McKinley; D C Bolton; S B Prusiner
Journal:  Cell       Date:  1983-11       Impact factor: 41.582

6.  Scrapie infectivity, fibrils and low molecular weight protein.

Authors:  H Diringer; H Gelderblom; H Hilmert; M Ozel; C Edelbluth; R H Kimberlin
Journal:  Nature       Date:  1983 Dec 1-7       Impact factor: 49.962

7.  Identification of a protein that purifies with the scrapie prion.

Authors:  D C Bolton; M P McKinley; S B Prusiner
Journal:  Science       Date:  1982-12-24       Impact factor: 47.728

Review 8.  Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).

Authors:  G G Glenner
Journal:  N Engl J Med       Date:  1980-06-12       Impact factor: 91.245

9.  Detection of proteinase K-resistant prion protein and infectivity in mouse spleen by 2 weeks after scrapie agent inoculation.

Authors:  R E Race; D Ernst
Journal:  J Gen Virol       Date:  1992-12       Impact factor: 3.891

10.  Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen.

Authors:  B Ehlers; H Diringer
Journal:  J Gen Virol       Date:  1984-08       Impact factor: 3.891
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  38 in total

1.  Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.

Authors:  K Doh-Ura; T Iwaki; B Caughey
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

2.  Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update.

Authors:  B Caughey; G J Raymond; S A Priola; D A Kocisko; R E Race; R A Bessen; P T Lansbury; B Chesebro
Journal:  Mol Biotechnol       Date:  1999-11       Impact factor: 2.695

3.  An atomic model for the pleated beta-sheet structure of Abeta amyloid protofilaments.

Authors:  L Li; T A Darden; L Bartolotti; D Kominos; L G Pedersen
Journal:  Biophys J       Date:  1999-06       Impact factor: 4.033

4.  Inhibition of protease-resistant prion protein accumulation in vitro by curcumin.

Authors:  Byron Caughey; Lynne D Raymond; Gregory J Raymond; Laura Maxson; Jay Silveira; Gerald S Baron
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

5.  Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent.

Authors:  V Beringue; K T Adjou; F Lamoury; T Maignien; J P Deslys; R Race; D Dormont
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

Review 6.  Protein-glycosaminoglycan interactions: infectiological aspects.

Authors:  D Sawitzky
Journal:  Med Microbiol Immunol       Date:  1996-02       Impact factor: 3.402

7.  Progress and problems in the biology, diagnostics, and therapeutics of prion diseases.

Authors:  Adriano Aguzzi; Mathias Heikenwalder; Gino Miele
Journal:  J Clin Invest       Date:  2004-07       Impact factor: 14.808

8.  A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell lines.

Authors:  Daryl Rhys Jones; William Alexander Taylor; Clive Bate; Monique David; Mourad Tayebi
Journal:  PLoS One       Date:  2010-03-22       Impact factor: 3.240

9.  Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status.

Authors:  Minna Groenning
Journal:  J Chem Biol       Date:  2009-08-20

10.  Evaluation of quinacrine treatment for prion diseases.

Authors:  A Barret; F Tagliavini; G Forloni; C Bate; M Salmona; L Colombo; A De Luigi; L Limido; S Suardi; G Rossi; F Auvré; K T Adjou; N Salès; A Williams; C Lasmézas; J P Deslys
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103
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