Literature DB >> 10775631

Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.

K Doh-Ura1, T Iwaki, B Caughey.   

Abstract

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.

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Year:  2000        PMID： 10775631      PMCID： PMC112015          DOI： 10.1128/jvi.74.10.4894-4897.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  Physical studies of conformational plasticity in a recombinant prion protein.

Authors:  H Zhang; J Stockel; I Mehlhorn; D Groth; M A Baldwin; S B Prusiner; T L James; F E Cohen
Journal:  Biochemistry       Date:  1997-03-25       Impact factor: 3.162

Review 2.  A review of drug-induced lysosomal disorders of the liver in man and laboratory animals.

Authors:  P Schneider; T A Korolenko; U Busch
Journal:  Microsc Res Tech       Date:  1997-02-15       Impact factor: 2.769

3.  Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].

Authors:  Y O Chernoff; S L Lindquist; B Ono; S G Inge-Vechtomov; S W Liebman
Journal:  Science       Date:  1995-05-12       Impact factor: 47.728

4.  Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts -- Japan, January 1979-May 1996.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1997-11-14       Impact factor: 17.586

5.  Potent inhibition of scrapie-associated PrP accumulation by congo red.

Authors:  B Caughey; R E Race
Journal:  J Neurochem       Date:  1992-08       Impact factor: 5.372

6.  Trial of a cysteine proteinase inhibitor, EST, in experimental chloroquine myopathy in rats.

Authors:  H Sugita; I Higuchi; M Sano; S Ishiura
Journal:  Muscle Nerve       Date:  1987 Jul-Aug       Impact factor: 3.217

7.  Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection.

Authors:  C F Farquhar; A G Dickinson
Journal:  J Gen Virol       Date:  1986-03       Impact factor: 3.891

8.  Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones.

Authors:  R E Race; B Caughey; K Graham; D Ernst; B Chesebro
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

9.  Inhibition of intracellular degradation of proteoglycans by leupeptin in rat ovarian granulosa cells.

Authors:  M Yanagishita
Journal:  J Biol Chem       Date:  1985-09-15       Impact factor: 5.157

10.  Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen.

Authors:  B Ehlers; H Diringer
Journal:  J Gen Virol       Date:  1984-08       Impact factor: 3.891
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  97 in total

Review 1.  Emergence and natural selection of drug-resistant prions.

Authors:  James Shorter
Journal:  Mol Biosyst       Date:  2010-04-27

Review 2.  Prion diseases: current understanding of epidemiology and pathogenesis, and therapeutic advances.

Authors:  Maria Caramelli; Giuseppe Ru; Pierluigi Acutis; Gianluigi Forloni
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

3.  Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo.

Authors:  David A Kocisko; Byron Caughey
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

4.  Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death.

Authors:  Jian-Hui Zhu; Craig Horbinski; Fengli Guo; Simon Watkins; Yasuo Uchiyama; Charleen T Chu
Journal:  Am J Pathol       Date:  2007-01       Impact factor: 4.307

5.  Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.

Authors:  Yuri Kawasaki; Keiichi Kawagoe; Chun-jen Chen; Kenta Teruya; Yuji Sakasegawa; Katsumi Doh-ura
Journal:  J Virol       Date:  2007-09-19       Impact factor: 5.103

6.  Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.

Authors:  Marcela V Karpuj; Kurt Giles; Sagit Gelibter-Niv; Michael R Scott; Vishwanath R Lingappa; Francis C Szoka; David Peretz; Wilfred Denetclaw; Stanley B Prusiner
Journal:  Mol Med       Date:  2007 Mar-Apr       Impact factor: 6.354

7.  New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.

Authors:  David A Kocisko; Gerald S Baron; Richard Rubenstein; Jiancao Chen; Salomon Kuizon; Byron Caughey
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  Poly-L-histidine inhibits prion propagation in a prion-infected cell line.

Authors:  Ryo Honda; Kei-Ichi Yamaguchi; Abdelazim Elsayed Elhelaly; Mitsuhiko Fuji; Kazuo Kuwata
Journal:  Prion       Date:  2018-08-17       Impact factor: 3.931

9.  Chemical induction of misfolded prion protein conformers in cell culture.

Authors:  Sina Ghaemmaghami; Julie Ullman; Misol Ahn; Susan St Martin; Stanley B Prusiner
Journal:  J Biol Chem       Date:  2009-12-02       Impact factor: 5.157

10.  Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells.

Authors:  Katarina M Luhr; Elin K Nordström; Peter Löw; Hans-Gustaf Ljunggren; Albert Taraboulos; Krister Kristensson
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103
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