Literature DB >> 8102118

Pharmacological activities of chlorpromazine involved in the inhibition of tumour necrosis factor production in vivo in mice.

R Bertini1, S Garattini, R Delgado, P Ghezzi.   

Abstract

Chlorpromazine (CPZ) was shown to inhibit tumour necrosis factor (TNF) production in vivo. Several drugs sharing one of the various pharmacological activities of CPZ were tested in endotoxin-treated mice. It was found that alpha-blockers (prazosin, idazoxan, phenoxybenzamine), antiserotoninergics (methysergide, methergoline) and antihistamine (chlorpheniramine, promethazine) also inhibited TNF production indicating that the effectiveness of CPZ in protecting from endotoxin shock is due to its multiple pharmacological activities.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8102118      PMCID： PMC1421854     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  4 in total

1.  Human tumor necrosis factor. Production, purification, and characterization.

Authors:  B B Aggarwal; W J Kohr; P E Hass; B Moffat; S A Spencer; W J Henzel; T S Bringman; G E Nedwin; D V Goeddel; R N Harkins
Journal:  J Biol Chem       Date:  1985-02-25       Impact factor: 5.157

2.  Potential therapeutic efficacy of inhibitors of human phospholipase A2 in septic shock.

Authors:  P Vadas; E Stefanski; W Pruzanski
Journal:  Agents Actions       Date:  1986-11

3.  Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.

Authors:  G D Martich; R L Danner; M Ceska; A F Suffredini
Journal:  J Exp Med       Date:  1991-04-01       Impact factor: 14.307

4.  Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock.

Authors:  M Gadina; R Bertini; M Mengozzi; M Zandalasini; A Mantovani; P Ghezzi
Journal:  J Exp Med       Date:  1991-06-01       Impact factor: 14.307
  4 in total
  15 in total

1.  The role of enteric bacteria in the pathogenesis of fatal cycloheximide intolerance in mice pretreated with dexamethasone, promethazine or nordihydroguaiaretic acid.

Authors:  E W Parry
Journal:  Inflamm Res       Date:  1996-07       Impact factor: 4.575

Review 2.  Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition.

Authors:  Borwin Bandelow; David Baldwin; Marianna Abelli; Blanca Bolea-Alamanac; Michel Bourin; Samuel R Chamberlain; Eduardo Cinosi; Simon Davies; Katharina Domschke; Naomi Fineberg; Edna Grünblatt; Marek Jarema; Yong-Ku Kim; Eduard Maron; Vasileios Masdrakis; Olya Mikova; David Nutt; Stefano Pallanti; Stefano Pini; Andreas Ströhle; Florence Thibaut; Matilde M Vaghi; Eunsoo Won; Dirk Wedekind; Adam Wichniak; Jade Woolley; Peter Zwanzger; Peter Riederer
Journal:  World J Biol Psychiatry       Date:  2016-07-15       Impact factor: 4.132

3.  The effects of dexamethasone and chlorpromazine on tumour necrosis factor-alpha, interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-10 in human volunteers.

Authors:  M W Bleeker; M G Netea; B J Kullberg; J Van der Ven-Jongekrijg; J W Van der Meer
Journal:  Immunology       Date:  1997-08       Impact factor: 7.397

4.  Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes.

Authors:  Iwona Karwaciak; Kaja Karaś; Anna Sałkowska; Joanna Pastwińska; Marcin Ratajewski
Journal:  Molecules       Date:  2022-06-07       Impact factor: 4.927

5.  Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice.

Authors:  M Mengozzi; G Fantuzzi; R Faggioni; A Marchant; M Goldman; S Orencole; B D Clark; M Sironi; F Benigni; P Ghezzi
Journal:  Immunology       Date:  1994-06       Impact factor: 7.397

6.  Long-Term Effect of Device-Guided Slow Breathing on Blood Pressure Regulation and Chronic Inflammation in Patients with Essential Hypertension Using a Wearable ECG Device.

Authors:  Chen-Hsu Wang; Hui-Wen Yang; Han-Luen Huang; Cheng-Yi Hsiao; Bun-Kai Jiu; Chen Lin; Men-Tzung Lo
Journal:  Acta Cardiol Sin       Date:  2021-03       Impact factor: 2.672

7.  Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy.

Authors:  Fuyan Xu; Huizhi Xi; Mengya Liao; Yiqian Zhang; Hongbo Ma; Mengling Wu; Qiang Xue; Hongbao Sun; Yiwen Zhang; Yong Xia
Journal:  Cancer Chemother Pharmacol       Date:  2022-01-24       Impact factor: 3.333

Review 8.  Phenoxybenzamine in complex regional pain syndrome: potential role and novel mechanisms.

Authors:  Mario A Inchiosa
Journal:  Anesthesiol Res Pract       Date:  2013-12-19

Review 9.  Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression.

Authors:  Eunsoo Won; Yong-Ku Kim
Journal:  Curr Neuropharmacol       Date:  2016       Impact factor: 7.363

10.  Increased serum interleukin-1beta and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication.

Authors:  Andrea Schmitt; Thomas Bertsch; Heike Tost; Andrea Bergmann; Uwe Henning; Ansgar Klimke; Peter Falkai
Journal:  Neuropsychiatr Dis Treat       Date:  2005-06       Impact factor: 2.570
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.