Literature DB >> 8101005

Effects of four antipsychotics on punished responding in rats.

J L Wiley1, A D Compton, J H Porter.   

Abstract

In Experiment 1, the benzodiazepine chlordiazepoxide (CDP), two typical antipsychotics, haloperidol (HAL) and chlorpromazine (CPZ), and the atypical antipsychotic clozapine (CLZ) were evaluated for antipunishment effects in rats in a modified Geller-Seifter conflict procedure [MULT fixed interval (FI) 60-s, fixed ratio (FR) 1 (food + shock)]. In Experiment 2, CDP and thioridazine (THD) were similarly tested. CLZ (2.5 and 5.0 mg/kg), but not HAL, CPZ, or THD, selectively increased punished responding, although the magnitude of effect was smaller than that observed for CDP. Possible serotonergic mechanisms for CLZ's action in this model and the possible importance of serotonergic activity for the development of other atypical antipsychotic drugs are discussed.

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Year:  1993        PMID： 8101005     DOI： 10.1016/0091-3057(93)90237-n

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  10 in total

1.  Effects of acute administration of nicotine, amphetamine, diazepam, morphine, and ethanol on risky decision-making in rats.

Authors:  Marci R Mitchell; Colin M Vokes; Amy L Blankenship; Nicholas W Simon; Barry Setlow
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2.  Effect of clozapine on locomotor activity and anxiety-related behavior in the neonatal mice administered MK-801.

Authors:  Neslihan Pınar; Kubra Akillioglu; Fatih Sefil; Harun Alp; Mustafa Sagir; Ahmet Acet
Journal:  Bosn J Basic Med Sci       Date:  2015-08-11       Impact factor: 3.363

3.  Similarity of clozapine's and olanzapine's acute effects on rats' lapping behavior.

Authors:  S Das; S C Fowler
Journal:  Psychopharmacology (Berl)       Date:  1996-02       Impact factor: 4.530

Review 4.  The age of anxiety: role of animal models of anxiolytic action in drug discovery.

Authors:  John F Cryan; Fabian F Sweeney
Journal:  Br J Pharmacol       Date:  2011-10       Impact factor: 8.739

5.  Modulation of mPer1 gene expression by anxiolytic drugs in mouse cerebellum.

Authors:  M Akiyama; T Kirihara; S Takahashi; Y Minami; Y Yoshinobu; T Moriya; S Shibata
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

6.  Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats.

Authors:  Tao Sun; Wei He; Gang Hu; Ming Li
Journal:  Pharmacol Biochem Behav       Date:  2010-02-16       Impact factor: 3.533

7.  Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.

Authors:  M J Benvenga; J D Leander
Journal:  Psychopharmacology (Berl)       Date:  1995-05       Impact factor: 4.530

8.  Acute and subchronic effects of clozapine on licking in rats: tolerance to disruptive effects on number of licks, but no tolerance to rhythm slowing.

Authors:  S Das; S C Fowler
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

9.  Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide.

Authors:  Alexa Mead; Ming Li; Shitij Kapur
Journal:  Pharmacol Biochem Behav       Date:  2008-10       Impact factor: 3.533

10.  Unlike haloperidol, clozapine slows and dampens rats' forelimb force oscillations and decreases force output in a press-while-licking behavioral task.

Authors:  S C Fowler; K H Davison; J A Stanford
Journal:  Psychopharmacology (Berl)       Date:  1994-09       Impact factor: 4.530
  10 in total

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