Literature DB >> 8101000

Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

S Rajagopalan1, D F Wan, G M Habib, A R Sepulveda, M R McLeod, R M Lebovitz, M W Lieberman.   

Abstract

The 5' region of the mouse gamma-glutamyltransferase (gamma GT; EC 2.3.2.2) gene has been cloned and analyzed. This analysis, combined with sequence information obtained from gamma GT cDNA clones, indicates that in mouse a single gamma GT gene codes for six different mRNAs that differ in their 5' sequences. Analysis of steady-state levels of gamma GT RNA reveals different expression patterns for these RNAs in different organs. The six different 5' sequences are widely separated within a 10-kb region and three of them show 75-86% identify with the three known rat gamma GT cDNAs. Although the heterogeneity of the 5' ends of gamma GT RNAs may be explained in part by alternative splicing, it is likely that multiple promoters are involved in their generation.

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Year:  1993        PMID： 8101000      PMCID： PMC46891          DOI： 10.1073/pnas.90.13.6179

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  HISTOCHEMICAL AND BIOCHEMICAL INVESTIGATIONS OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN THE TISSUES OF MAN AND LABORATORY RODENTS.

Authors:  Z ALBERT; J ORLOWSKA; M ORLOWSKI; A SZEWCZUK
Journal:  Acta Histochem       Date:  1964-05-30       Impact factor: 2.479

2.  Higher transpeptidation activity and broad acceptor specificity of gamma-glutamyltransferases of tumors.

Authors:  N Tateishi; T Higashi; T Nomura; A Naruse; K Nakashima
Journal:  Gan       Date:  1976-04

3.  Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue.

Authors:  S Jaken; M Mason
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.

Authors:  R Cameron; J Kellen; A Kolin; A Malkin; E Farber
Journal:  Cancer Res       Date:  1978-03       Impact factor: 12.701

5.  -Glutamyl transpeptidase in transplantable, chemically induced rat hepatomas and "spontaneous" mouse hepatomas.

Authors:  S Fiala; A E Fiala; B Dixon
Journal:  J Natl Cancer Inst       Date:  1972-05       Impact factor: 13.506

6.  Bovine lens -glutamyl transpeptidase.

Authors:  W B Rathbun; K Wicker
Journal:  Exp Eye Res       Date:  1973-02       Impact factor: 3.467

7.  Alteration by phenobarbital of membrane-associated enzymes including gamma glutamyl transpeptidase in mouse liver neoplasms.

Authors:  G M Williams; T Ohmori; S Katayama; J M Rice
Journal:  Carcinogenesis       Date:  1980       Impact factor: 4.944

8.  Demonstration of gamma-glutamyl transferase, alkaline phosphatase, CEA and HCG in human lung cancer.

Authors:  K Dempo; K A Elliott; W Desmond; W H Fishman
Journal:  Oncodev Biol Med       Date:  1981

9.  Localization of gamma-glutamyl transpeptidase in hamster buccal pouch epithelium treated with 7,12-dimethylbenz[a]anthracene.

Authors:  D B Solt
Journal:  J Natl Cancer Inst       Date:  1981-07       Impact factor: 13.506

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  7 in total

1.  Housekeeping promoter 5'pcmah-2 of pig CMP-N-acetylneuraminic acid hydroxylase gene for NeuGc expression.

Authors:  Kwon-Ho Song; Choong-Hwan Kwak; Un-Ho Jin; Sun-Hyung Ha; Jun-Young Park; Fukushi Abekura; Young-Chae Chang; Seung-Hak Cho; Kichoon Lee; Tae-Wook Chung; Ki-Tae Ha; Young-Choon Lee; Cheorl-Ho Kim
Journal:  Glycoconj J       Date:  2016-05-17       Impact factor: 2.916

2.  Characterization of the promoter of human adipocyte hormone-sensitive lipase.

Authors:  J Grober; H Laurell; R Blaise; B Fabry; S Schaak; C Holm; D Langin
Journal:  Biochem J       Date:  1997-12-01       Impact factor: 3.857

3.  Expression of multiple glutamate transporter splice variants in the rodent testis.

Authors:  Aven Lee; Ashley R Anderson; Amanda C Barnett; Anthony Chan; David V Pow
Journal:  Asian J Androl       Date:  2010-12-20       Impact factor: 3.285

4.  The human gamma-glutamyltransferase gene family.

Authors:  Nora Heisterkamp; John Groffen; David Warburton; Tam P Sneddon
Journal:  Hum Genet       Date:  2008-03-21       Impact factor: 4.132

5.  The canine betaine gamma-amino-n-butyric acid transporter gene: diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner.

Authors:  M Takenaka; S M Bagnasco; A S Preston; S Uchida; A Yamauchi; H M Kwon; J S Handler
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-14       Impact factor: 11.205

Review 6.  gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

Authors:  M W Lieberman; R Barrios; B Z Carter; G M Habib; R M Lebovitz; S Rajagopalan; A R Sepulveda; Z Z Shi; D F Wan
Journal:  Am J Pathol       Date:  1995-11       Impact factor: 4.307

Review 7.  Phase III elimination: another two-edge sword.

Authors:  M Vore
Journal:  Environ Health Perspect       Date:  1994-05       Impact factor: 9.031
  7 in total

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