Literature DB >> 809982

Effects of benzalkonium chloride upon the corneal epithelium studied with scanning electron microscopy.

A M Tonjum.   

Abstract

The corneal surface of rabbits and vervet monkeys was studied by means of scanning electron microscopy after the influence of the cationic surfactant, benzalkonium chloride. The concentration of the drug was 0.02% or 0.01% and the exposure time was 2 or 4 min. The corneas treated with the drug had characteristic changes with small holes or more extensive lesions of the superficial cell membranes, and loss of microvilli or microplicae. The damage was considered to be due to the lytic effect of benzalkonium chloride upon the plasma membranes.

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Year:  1975        PMID： 809982     DOI： 10.1111/j.1755-3768.1975.tb01167.x

Source DB:  PubMed          Journal:  Acta Ophthalmol (Copenh)        ISSN： 0001-639X


  9 in total

Review 1.  Antibiotic therapy for ocular infection.

Authors:  R W Snyder; D B Glasser
Journal:  West J Med       Date:  1994-12

2.  Effect of topical beta blockers on corneal epithelial wound healing in the rabbit.

Authors:  J J Reidy; J Zarzour; H W Thompson; R W Beuerman
Journal:  Br J Ophthalmol       Date:  1994-05       Impact factor: 4.638

3.  Corneal toxicity secondary to inadvertent use of benzalkonium chloride preserved viscoelastic material in cataract surgery.

Authors:  H Eleftheriadis; M Cheong; S Sandeman; P P Syam; P Brittain; G K Klintworth; A Lloyd; C Liu
Journal:  Br J Ophthalmol       Date:  2002-03       Impact factor: 4.638

4.  The effect of topical cyclosporin A on the rabbit cornea. A clinical and electron microscopic study.

Authors:  W Behrens-Baumann; S Theuring; H Brewitt
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1986       Impact factor: 3.117

5.  Ocular inflammation and corneal permeability alteration by benzalkonium chloride in rats: a protective effect of a myosin light chain kinase inhibitor.

Authors:  Marie Thérèse Droy-Lefaix; Lionel Bueno; Philippe Caron; Eric Belot; Olivier Roche
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-04-17       Impact factor: 4.799

6.  The effect of topical parasympathomimetics on corneal epithelial healing in rabbits.

Authors:  H Er
Journal:  Doc Ophthalmol       Date:  1997       Impact factor: 2.379

Review 7.  Myenteric Denervation of the Gut with Benzalkonium Chloride: A Review of Forty Years of an Experimental Model.

Authors:  Sérgio Britto Garcia; Stefânia Bovo Minto; Isabela de Souza Marques; Vinicius Kannen
Journal:  Can J Gastroenterol Hepatol       Date:  2019-02-03

8.  EFFECT OF LUBRICANTS ON CORNEAL THICKNESS AFTER VITRECTOMY.

Authors:  Diane T Siegel; G Baker Hubbard; Jiong Yan; Blaine Cribbs; Nieraj Jain; Steve Yeh; Diem Bui; Jesse Smith; Scott Barb; William Pearce; Laura Ward; Andrew M Hendrick
Journal:  Retina       Date:  2020-08       Impact factor: 3.975

9.  Ocular toxicity of benzalkonium chloride homologs compared with their mixtures.

Authors:  Akihiko Okahara; Hidetoshi Tanioka; Koichi Takada; Kouichi Kawazu
Journal:  J Toxicol Pathol       Date:  2013-12-26       Impact factor: 1.628
  9 in total

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