| Literature DB >> 8099142 |
J W van der Meer1, R S Weening, P T Schellekens, I P van Munster, F M Nagengast.
Abstract
Primary immunodeficiency disorders can predispose to certain malignancies but hitherto no such relation has been established for X-linked agammaglobulinaemia (XLA). We have diagnosed rapidly progressive colorectal cancer in 3 unrelated young adults with XLA. We could find no explanation for the tumours. Since the calculated incidence of rectosigmoid cancer is increased 30-fold in patients with XLA, we advise the screening of these individuals, and perhaps people with other agammaglobulinaemias, for colorectal cancer.Entities:
Mesh:
Year: 1993 PMID: 8099142 DOI: 10.1016/0140-6736(93)90883-i
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321