| Literature DB >> 8098956 |
A Aneiros1, I García, J R Martínez, A L Harvey, A J Anderson, D L Marshall, A Engström, U Hellman, E Karlsson.
Abstract
A peptide toxin affecting potassium channels was isolated from the sea anemone Bunodosoma granulifera. It facilitates acetylcholine release at avian neuromuscular junctions, competes with dendrotoxin I, a probe for voltage-dependent potassium channels, for binding to synaptosomal membranes of rat brain with a Ki of 0.7 nM and suppresses K+ currents in rat dorsal root ganglion neurones in culture. It represents a new structural type of potassium channel toxin with the sequence V1RCDWFKETA10CRHAKSLGNC20RTSQKYRANC30AKTLQCC37 (M(r) 4275, three disulfides).Entities:
Mesh：
Substances：
Year: 1993 PMID： 8098956 DOI： 10.1016/0304-4165(93)90082-j
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002