| Literature DB >> 8095573 |
T E Taylor1, B A Wills, P Kazembe, M Chisale, J J Wirima, E Y Ratsma, M E Molyneux.
Abstract
Artemisinin compounds clear parasitaemia more rapidly than other drugs do in both mild and severe malaria, but no advantage in clinical efficacy has been shown. We have compared artemether treatment with standard quinine treatment in Malawian children with cerebral malaria. 65 unconscious children were randomly allocated to intravenous quinine (n = 37) or intramuscular artemether (n = 28) treatment. The two groups were well matched for various prognostic features. Median parasite clearance times were shorter in the artemether group (28 [interquartile range 18-34] vs 40 [36-44] h in the quinine group, p = 0.0002). Coma resolution times were also shorter with artemether than with quinine (8 [4-15] vs 14 [10-36] h, p = 0.01).Entities:
Keywords: Africa; Africa South Of The Sahara; Age Factors; Biology; Central Nervous System; Central Nervous System Effects; Cerebrovascular Effects; Child; Child Mortality; Delivery Of Health Care; Demographic Factors; Developing Countries; Diseases; Drugs; Eastern Africa; English Speaking Africa; Health; Health Services; Malaria; Malawi; Medicine; Mortality; Neurologic Effects; Parasitic Diseases; Physiology; Plants, Medicinal; Population; Population Characteristics; Population Dynamics; Research Report; Signs And Symptoms; Treatment; Youth
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Year: 1993 PMID： 8095573 DOI： 10.1016/0140-6736(93)90423-e
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321