Literature DB >> 8094251

Anxiogenic effect of phenylethylamine and amphetamine in the elevated plus-maze in mice and its attenuation by ethanol.

I P Lapin1.   

Abstract

In previous experiments beta-phenylethylamine (PEA), like the standard anxiogens caffeine, pentylenetetrazole, and yohimbine, has exhibited an anxiogenic effect in the two animal models of anxiety: the social interaction test and the conflict situation test. In the present study, PEA acts as an anxiogen in an elevated plus-maze, diminishing (compared to controls) the ratio of entries into open arms over the total number of entries and shortening the time spent in the open arms. DL-Amphetamine sulfate (AMPH) also had a similar action. These data support the previous suggestion that PEA may belong to the group of endogenous anxiety-inducing compounds. Pretreatment with ethanol prevented the effects of both PEA and AMPH.

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Year:  1993        PMID： 8094251     DOI： 10.1016/0091-3057(93)90305-d

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


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