Literature DB >> 26092759

Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction.

Li Jing1, Jun-Xu Li2.   

Abstract

Abuse of and addiction to psychostimulants remains a challenging clinical issue; yet no effective pharmacotherapy is available. Trace amine associated receptor 1 (TAAR 1) is increasingly recognized as a novel drug target that participates in the modulation of drug abuse. This review analyzed existing preclinical evidence from electrophysiological, biochemical to behavioral aspects regarding the functional interactions between TAAR 1 and dopaminergic system. TAAR 1 knockout mice demonstrate increased sensitivity to dopaminergic activation while TAAR 1 agonists reduce the neurochemical effects of cocaine and amphetamines, attenuate abuse- and addiction-related behavioral effects of cocaine and methamphetamine. It is concluded that TAAR 1 activation functionally modulates the dopaminergic activity and TAAR 1 agonists appear to be promising pharmacotherapies against psychostimulant addiction.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Addiction; Behavior; Cocaine; Methamphetamine; TAAR 1

Mesh：

Substances：

Year:  2015        PMID： 26092759      PMCID： PMC4532615          DOI： 10.1016/j.ejphar.2015.06.019

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  61 in total

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4.  Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.

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Journal:  Mol Pharmacol       Date:  2001-12       Impact factor: 4.436

5.  Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders.

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Journal:  Neuropsychopharmacology       Date:  2005-04       Impact factor: 7.853

6.  Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro.

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Journal:  J Pharmacol Exp Ther       Date:  2007-01-18       Impact factor: 4.030

7.  Anxiogenic effect of phenylethylamine and amphetamine in the elevated plus-maze in mice and its attenuation by ethanol.

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8.  Dopaminergic response to drug words in cocaine addiction.

Authors:  Rita Z Goldstein; Dardo Tomasi; Nelly Alia-Klein; Jean Honorio Carrillo; Thomas Maloney; Patricia A Woicik; Ruiliang Wang; Frank Telang; Nora D Volkow
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Review 9.  The potential of trace amines and their receptors for treating neurological and psychiatric diseases.

Authors:  M D Berry
Journal:  Rev Recent Clin Trials       Date:  2007-01

10.  Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.

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  12 in total

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2.  Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior.

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Journal:  J Neurosci       Date:  2017-01-25       Impact factor: 6.167

3.  "TAARgeting Addiction"--The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference.

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5.  A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor.

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6.  Hypothesizing that, A Pro-Dopamine Regulator (KB220Z) Should Optimize, but Not Hyper-Activate the Activity of Trace Amine-Associated Receptor 1 (TAAR-1) and Induce Anti-Craving of Psychostimulants in the Long-Term.

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7.  Insight of Captagon Abuse by Chemogenomics Knowledgebase-guided Systems Pharmacology Target Mapping Analyses.

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8.  Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1.

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9.  Effects of Trace Amine-associated Receptor 1 Agonists on the Expression, Reconsolidation, and Extinction of Cocaine Reward Memory.

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Review 10.  TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg.

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