Literature DB >> 8094065

A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus.

J B Lichter1, J Wu, A R Brooks-Wilson, M Difillipantonio, S Brewster, D C Ward, P J Goodfellow, K K Kidd.   

Abstract

Familial multiple endocrine neoplasia type 2A (MEN 2A) is a cancer syndrome that is inherited as an autosomal dominant with high penetrance. Its clinical features are medullary carcinoma of the thyroid, pheochromocytomas, and hyperparathyroidism. A new polymorphic locus D10S97 (probe: KW6 delta SacI) detects a codominant EcoRI polymorphism that is tightly linked to the MEN2A locus. The peak lod score for linkage between D10S97 with MEN2A is 13.03 at theta = 0.00. The polymorphic locus D10S97 maps, by linkage analysis, into the previously defined interval between FNRB and RBP3 to which MEN2A has been assigned. We present physical mapping data showing that the probe pKW6 originates from 10p13 and that the polymorphic locus D10S97 in 10q11.2 is detected by cross-hybridization.

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Year:  1993        PMID： 8094065     DOI： 10.1007/bf00217451

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  22 in total

Review 1.  Report of the committee on the genetic constitution of chromosome 10.

Authors:  N E Simpson; H Cann
Journal:  Cytogenet Cell Genet       Date:  1990

2.  Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2----q26.3.

Authors:  K H Astrin; C A Warner; H W Yoo; P J Goodfellow; S F Tsai; R J Desnick
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

3.  Studies of three Amerindian populations using nuclear DNA polymorphisms.

Authors:  J R Kidd; F L Black; K M Weiss; I Balazs; K K Kidd
Journal:  Hum Biol       Date:  1991-12       Impact factor: 0.553

4.  High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones.

Authors:  P Lichter; C J Tang; K Call; G Hermanson; G A Evans; D Housman; D C Ward
Journal:  Science       Date:  1990-01-05       Impact factor: 47.728

5.  Regional localization of polymorphic markers on chromosome 10 by physical and genetic mapping.

Authors:  C G Mathew; W Wakeling; E Jones; D Easton; R Fisher; C Strong; B Smith; K Chin; P Little; Y Nakamura
Journal:  Ann Hum Genet       Date:  1990-05       Impact factor: 1.670

6.  An EcoRI polymorphism identified by KW6 (D10S97) on chromosome 10.

Authors:  J S Wu; K K Kidd
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

7.  A high-resolution meiotic mapping panel for the pericentromeric region of chromosome 10.

Authors:  J B Lichter; J Wu; D Miller; P J Goodfellow; K K Kidd
Journal:  Genomics       Date:  1992-07       Impact factor: 5.736

Review 8.  Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors:  D Botstein; R L White; M Skolnick; R W Davis
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025

9.  The genetic defect in multiple endocrine neoplasia type 2A maps next to the centromere of chromosome 10.

Authors:  J S Wu; N L Carson; S Myers; A J Pakstis; J R Kidd; C M Castiglione; L Anderson; L S Hoyle; M Genel; M Verdy
Journal:  Am J Hum Genet       Date:  1990-03       Impact factor: 11.025

10.  Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region.

Authors:  J S Wu; K K Kidd
Journal:  Hum Genet       Date:  1990-02       Impact factor: 4.132
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