Literature DB >> 1353475

A high-resolution meiotic mapping panel for the pericentromeric region of chromosome 10.

J B Lichter1, J Wu, D Miller, P J Goodfellow, K K Kidd.   

Abstract

Familial multiple endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer syndrome characterized by tumors in tissues derived from the neural crest. The disease manifests as medullary carcinoma of the thyroid, pheochromocytoma, and hyperparathyroidism. The MEN2A locus has been mapped near the centromere of chromosome 10 by linkage analysis. Statistical analyses have not resolved the location of MEN2A among several close markers. We have used our family material to refine the positions of 36 identified and confirmed crossovers among the markers most closely linked to MEN2A. This high-resolution meiotic mapping panel will help order loci in this pericentromeric region and narrow the region in which MEN2A maps.

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Year:  1992        PMID： 1353475     DOI： 10.1016/0888-7543(92)90131-b

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  5 in total

1.  Construction of radiation-reduced hybrids and their use in mapping of microclones from chromosome 10p11.2-q11.2.

Authors:  S Fujita; E Shin; T Nakamura; H Kurahashi; Y Kaneda; K Tanaka; T Mori; S Takai; I Nishisho
Journal:  Jpn J Hum Genet       Date:  1993-12

2.  A strategy for constructing high-resolution genetic maps of the human genome: a genetic map of chromosome 17p, ordered with meiotic breakpoint-mapping panels.

Authors:  S C Gerken; H Albertsen; T Elsner; L Ballard; P Holik; E Lawrence; M Moore; X Zhao; R White
Journal:  Am J Hum Genet       Date:  1995-02       Impact factor: 11.025

3.  A multiple interval physical map of the pericentromeric region of human chromosome 10.

Authors:  A Tunnacliffe; M S Jackson; E Gardner; D R Love; J K Moore; S E Mole; L M Mulligan; A Graham; G Finocchiaro; S Orstavik
Journal:  Hum Genet       Date:  1994-03       Impact factor: 4.132

4.  A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus.

Authors:  J B Lichter; J Wu; A R Brooks-Wilson; M Difillipantonio; S Brewster; D C Ward; P J Goodfellow; K K Kidd
Journal:  Hum Genet       Date:  1993-01       Impact factor: 4.132

5.  A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.

Authors:  T C Lairmore; S Dou; J R Howe; D Chi; K Carlson; R Veile; S K Mishra; S A Wells; H Donis-Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205
  5 in total

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