| Literature DB >> 8093354 |
Q R Liu1, S Mandiyan, B López-Corcuera, H Nelson, N Nelson.
Abstract
A rat cDNA clone encoding the novel membrane protein of the neurotransmitter transporters family was cloned and sequenced. The cDNA was identified as a transcript of the gene NTT4 of which a partial genomic clone was previously sequenced. Alignment of the amino acid sequence of NTT4 with other members of the neurotransmitter transporter family revealed a marked deviation from the conserved structure of all other members of the family. The largest extracellular loop with a potential glycosylation site was identified between membrane segments 7 and 8. The protein retains the common glycosylated loop between transmembrane helices 3 and 4 in all members of the family. The transcript of NTT4 was found exclusively in the central nervous system and is more abundant in the cerebellum and the cerebral cortex.Entities:
Mesh：
Substances：
Year: 1993 PMID： 8093354 DOI： 10.1016/0014-5793(93)81145-p
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124